The role of human papillomavirus in head and neck cancer in Senegal.
The role of human papillomavirus in head and neck cancer in Senegal.
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DOI：
10.1186/1750-9378-8-14
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发表时间：
2013-04-17
影响因子：
3.7
通讯作者：
Sanjosé Sd
中科院分区：
文献类型：
--
作者：
Ndiaye C;Alemany L;Diop Y;Ndiaye N;Diémé MJ;Tous S;Klaustermeier JE;Alejo M;Castellsagué X;Bosch FX;Trottier H;Sanjosé Sd
探索人乳头瘤病毒（HPV）在头颈癌（HNC）中的存在及其作用是评估HPV预防性疫苗潜在影响的必要步骤。评估塞内加尔HNC中HPV的患病率和致癌作用。这是一项多中心横断面研究。从塞内加尔的4个病理实验室收集2002年至2010年间诊断为侵袭性HNC病例的石蜡包埋块。采用PCR和DEIA检测HPV DNA的存在，并用LiPA25进行基因分型。进行微管蛋白分析以评估DNA质量。检测HPV dna阳性病例p16INK4a的表达。117例纳入分析：男性71%，平均年龄52岁（SD±18.3），96%为鳞状细胞癌。对41例口腔肿瘤、64例喉部肿瘤、5例口咽肿瘤和7例咽肿瘤进行了分析。只有4例（3.4%;95% CI = 0.9%-8.5%）携带HPV DNA。检出的HPV类型分别为HPV16、HPV35和HPV45。然而，在hpv阳性病例中，没有p16INK4a过表达。我们的研究结果表明，塞内加尔HNC的HPV DNA患病率非常低，这表明HPV不是这些癌症的强烈危险因素。需要更多更大规模的研究来证实这些发现，并探索该地区特有的其他潜在风险因素。
Exploring the presence and role of human papillomavirus (HPV) in head and neck cancer (HNC) is a necessary step to evaluate the potential impact of HPV prophylactic vaccines. To assess the prevalence and oncogenic role of HPV in HNC in Senegal. This is a multicenter cross-sectional study. Paraffin-embedded blocks of cases diagnosed with invasive HNC between 2002 and 2010 were collected from 4 pathology laboratories in Senegal. Presence of HPV DNA was determined by PCR and DEIA, and genotyping performed with LiPA25. Tubulin analysis was performed to assess DNA quality. HPV DNA-positive cases were tested for p16INK4a expression. A total of 117 cases were included in the analysis: 71% were men, mean age was 52 years old (SD ±18.3), and 96% of cases were squamous cell carcinoma. Analysis was performed on 41 oral cavity tumors, 64 laryngeal tumors, 5 oropharyngeal tumors and 7 pharyngeal tumors. Only four cases (3.4%; 95% CI = 0.9%-8.5%) harbored HPV DNA. HPV types detected were HPV16, HPV35 and HPV45. However, among HPV-positive cases, none showed p16INK4a overexpression. Our findings indicate that HPV DNA prevalence in HNC in Senegal is very low, suggesting that HPV is not a strong risk factor for these cancers. Additional larger studies are needed to confirm these findings and explore other potential risk factors specific to the region.
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影响因子：
5
作者：
Guha, Neela;Boffetta, Paolo;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
6.4
作者：
Ferlay, Jacques;Shin, Hai-Rim;Parkin, Donald Maxwell
通讯作者：
Parkin, Donald Maxwell
影响因子：
6.4
作者：
Jung, Alain C.;Briolat, Jenny;Wasylyk, Bohdan
通讯作者：
Wasylyk, Bohdan
影响因子：
6.4
作者：
Smeets, Serge J.;Hesselink, Albertus T.;Brakenhoff, Ruud H.
通讯作者：
Brakenhoff, Ruud H.
DOI：
10.1158/1940-6207.capr-09-0149
发表时间：
2009-09
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Settle K;Posner MR;Schumaker LM;Tan M;Suntharalingam M;Goloubeva O;Strome SE;Haddad RI;Patel SS;Cambell EV 3rd;Sarlis N;Lorch J;Cullen KJ
通讯作者：
Cullen KJ