In vitro plant tissue culture: means for production of biological active compounds.
In vitro plant tissue culture: means for production of biological active compounds.
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DOI：
10.1007/s00425-018-2910-1
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发表时间：
2018-07
期刊：
影响因子：
4.3
通讯作者：
García-Lara S
中科院分区：
文献类型：
--
作者：
Espinosa-Leal CA;Puente-Garza CA;García-Lara S
植物组织培养作为连续生产活性化合物的重要工具，包括次生代谢物和工程分子。新的方法(基因编辑、非生物胁迫)可以改进这项技术。长期以来，人类依赖植物提供食物、住所，最重要的是药物。当今的药物通常是以植物来源的代谢物为基础的，新产品不断被发现。然而，始终如一的植物药物供应经常受到影响。生产重要植物活性化合物的一种替代方法是体外植物组织培养，因为它通过消除对野生植物的依赖来确保独立于地理条件。植物转化还允许进一步利用植物生产工程化合物，如疫苗和多种药物。本文综述了目前植物组织培养产生的重要生物活性物质及其生产的基本方法和植物。
Plant tissue culture as an important tool for the continuous production of active compounds including secondary metabolites and engineered molecules. Novel methods (gene editing, abiotic stress) can improve the technique. Humans have a long history of reliance on plants for a supply of food, shelter and, most importantly, medicine. Current-day pharmaceuticals are typically based on plant-derived metabolites, with new products being discovered constantly. Nevertheless, the consistent and uniform supply of plant pharmaceuticals has often been compromised. One alternative for the production of important plant active compounds is in vitro plant tissue culture, as it assures independence from geographical conditions by eliminating the need to rely on wild plants. Plant transformation also allows the further use of plants for the production of engineered compounds, such as vaccines and multiple pharmaceuticals. This review summarizes the important bioactive compounds currently produced by plant tissue culture and the fundamental methods and plants employed for their production.
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