A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivo imaging.
A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivo imaging.
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DOI：
10.1002/cmmi.1628
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发表时间：
2015-05
影响因子：
--
通讯作者：
Sun, Phillip Zhe
中科院分区：
文献类型：
--
作者：
Kim, Jinsuh;Wu, Yin;Guo, Yingkun;Zheng, Hairong;Sun, Phillip Zhe
关键词：
化学交换饱和转移（CEST）MRI是一种多功能成像方法，可探测大量水和可交换质子之间的化学交换。CEST成像通过可交换质子选择性饱和后的大量水信号变化间接检测稀释的不稳定质子，这提供了显著的灵敏度增强，并引发了许多生物医学应用。在过去的十年中，CEST成像技术由于来自多个领域的贡献而迅速发展，包括CEST数学模型的开发、创新的造影剂设计、灵敏的数据采集方案、有效的场不均匀性校正算法和定量CEST（qCEST）分析。然而，构成明显的CEST加权效应基础的CEST系统是复杂的。实验上可测量的CEST效应不仅取决于诸如CEST试剂浓度、pH和温度的参数，而且还取决于弛豫速率、磁场强度，更重要的是，实验参数包括重复时间、RF辐照幅度和方案以及图像读出。使用qCEST分析对基础CEST系统的透彻理解可以增强常规成像的诊断能力。在这篇综述中，我们提供了一个简明的解释CEST采集方法和处理算法，包括其优点和局限性，优化和量化CEST MRI实验。
Chemical exchange saturation transfer (CEST) MRI is a versatile imaging method that probes the chemical exchange between bulk water and exchangeable protons. CEST imaging indirectly detects dilute labile protons via bulk water signal changes following selective saturation of exchangeable protons, which offers substantial sensitivity enhancement and has sparked numerous biomedical applications. Over the past decade, CEST imaging techniques have rapidly evolved due to contributions from multiple domains, including the development of CEST mathematical models, innovative contrast agent designs, sensitive data acquisition schemes, efficient field inhomogeneity correction algorithms, and quantitative CEST (qCEST) analysis. The CEST system that underlies the apparent CEST-weighted effect, however, is complex. The experimentally measurable CEST effect depends not only on parameters such as CEST agent concentration, pH and temperature, but also on relaxation rate, magnetic field strength and more importantly, experimental parameters including repetition time, RF irradiation amplitude and scheme, and image readout. Thorough understanding of the underlying CEST system using qCEST analysis may augment the diagnostic capability of conventional imaging. In this review, we provide a concise explanation of CEST acquisition methods and processing algorithms, including their advantages and limitations, for optimization and quantification of CEST MRI experiments.
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DOI：
10.1016/j.jconrel.2014.02.005
发表时间：
2014-04-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Chan KW;Yu T;Qiao Y;Liu Q;Yang M;Patel H;Liu G;Kinzler KW;Vogelstein B;Bulte JW;van Zijl PC;Hanes J;Zhou S;McMahon MT
通讯作者：
McMahon MT
化学交换饱和转移在7 t的发展。
影响因子：
3.3
作者：
Dula, Adrienne N.;Asche, Elizabeth M.;Landman, Bennett A.;Welch, E. Brian;Pawate, Siddharama;Sriram, Subramaniam;Gore, John C.;Smith, Seth A.
通讯作者：
Smith, Seth A.
影响因子：
3.3
作者：
Desmond, Kimberly L.;Moosvi, Firas;Stanisz, Greg J.
通讯作者：
Stanisz, Greg J.
影响因子：
3.3
作者：
Chen, Jin-Hong;Sambol, Elliot B.;Singer, Samuel
通讯作者：
Singer, Samuel
影响因子：
15
作者：
Friedman, Joshua I.;McMahon, Michael T.;Stivers, James T.;Van Zijl, Peter C. M.
通讯作者：
Van Zijl, Peter C. M.