Bottom-up dependent gating of frontal signals in early visual cortex.
Bottom-up dependent gating of frontal signals in early visual cortex.
复制标题
早期视觉皮层中额叶信号的自下而上的门控。
DOI:
10.1126/science.1153276
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发表时间:
2008-07-18
期刊:
影响因子:
--
通讯作者:
Vanduffel W
中科院分区:
文献类型:
--
作者:
Ekstrom LB;Roelfsema PR;Arsenault JT;Bonmassar G;Vanduffel W
The frontal eye field (FEF) is one of several cortical regions thought to modulate sensory inputs. Moreover, several hypotheses suggest that the FEF can only modulate early visual areas in the presence of a visual stimulus. To test for bottom-up gating of frontal signals, we microstimulated subregions in the FEF of two monkeys and measured the effects throughout the brain with functional magnetic resonance imaging. The activity of higher-order visual areas was strongly modulated by FEF stimulation, independent of visual stimulation. In contrast, FEF stimulation induced a topographically specific pattern of enhancement and suppression in early visual areas, but only in the presence of a visual stimulus. Modulation strength depended on stimulus contrast and on the presence of distractors. We conclude that bottom-up activation is needed to enable top-down modulation of early visual cortex and that stimulus saliency determines the strength of this modulation.
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