Bottom-up dependent gating of frontal signals in early visual cortex.

Bottom-up dependent gating of frontal signals in early visual cortex.
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早期视觉皮层中额叶信号的自下而上的门控。

DOI:
10.1126/science.1153276
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发表时间:
2008-07-18
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Vanduffel W
Vanduffel W
中科院分区:
其他
文献类型:
--
作者:
Ekstrom LB;Roelfsema PR;Arsenault JT;Bonmassar G;Vanduffel W

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额叶眼区(frontal eye field,FEF)是调节感觉输入的几个皮层区域之一。此外,一些假设表明,FEF只能在视觉刺激的存在下调节早期视觉区。为了测试额叶信号的自下而上的门控,我们微刺激了两只猴子的FEF子区域,并利用功能性磁共振成像测量了整个大脑的影响。高阶视觉区的活动强烈调制的FEF刺激,独立的视觉刺激。与此相反,FEF刺激诱导的地形特异性模式的增强和抑制在早期的视觉领域,但只有在存在的视觉刺激。调制强度依赖于刺激对比度和干扰物的存在。我们的结论是,自下而上的激活是必要的,使自上而下的调制早期视觉皮层和刺激显着性决定了这种调制的强度。
The frontal eye field (FEF) is one of several cortical regions thought to modulate sensory inputs. Moreover, several hypotheses suggest that the FEF can only modulate early visual areas in the presence of a visual stimulus. To test for bottom-up gating of frontal signals, we microstimulated subregions in the FEF of two monkeys and measured the effects throughout the brain with functional magnetic resonance imaging. The activity of higher-order visual areas was strongly modulated by FEF stimulation, independent of visual stimulation. In contrast, FEF stimulation induced a topographically specific pattern of enhancement and suppression in early visual areas, but only in the presence of a visual stimulus. Modulation strength depended on stimulus contrast and on the presence of distractors. We conclude that bottom-up activation is needed to enable top-down modulation of early visual cortex and that stimulus saliency determines the strength of this modulation.
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