Joint Investigation of 2-Month Post-diagnosis IgG Antibody Levels and Psychological Measures for Assessing Longer Term Multi-Faceted Recovery Among COVID-19 Cases in Northern Cyprus.
Joint Investigation of 2-Month Post-diagnosis IgG Antibody Levels and Psychological Measures for Assessing Longer Term Multi-Faceted Recovery Among COVID-19 Cases in Northern Cyprus.
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DOI：
10.3389/fpubh.2020.590096
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发表时间：
2020
影响因子：
5.2
通讯作者：
Çakal H
中科院分区：
文献类型：
--
作者：
Barin B;Yoldascan BE;Savaskan F;Ozbalikci G;Karaderi T;Çakal H
COVID-19爆发后，关注COVID-19感染的长期影响和完全康复的多学科研究仍然很少。关于长期后果，生理效应的生物标志物以及心理体验对于全面了解COVID-19的完全康复具有重要意义。本研究调查了来自北方塞浦路斯第一波（2020年3月至4月）爆发的COVID-19患者亚组中的IgG抗体滴度和COVID-19作为活动感染期（诊断后约2个月）后的创伤经历的影响。抗体滴度和心理调查措施与基线特征和疾病严重程度的关联进行了探讨，并评估了各种措施之间的相关性。在47项IgG抗体血清学检测中，39项（83%）为阳性。我们发现的趋势表明，经历严重或危重COVID-19疾病的个体和/或患有合并症的个体在生理和精神上受到更严重的影响，与患有轻度疾病和没有合并症的个体相比，IgG滴度更高，心理体验更消极。我们亦观察到超过一半的COVID-19个案有负面的心理体验，受到家人╱朋友的歧视及言语骚扰╱侮辱。综上所述，作为第一项共同评估COVID-19中免疫反应和精神状态的研究，我们的研究结果表明，需要在更大样本人群中进行进一步的多学科研究以及社区干预计划，以全面解决COVID-19对病例的生理和心理影响。
Following the outbreak of COVID-19, multidisciplinary research focusing on the long-term effects of the COVID-19 infection and the complete recovery is still scarce. With regards to long-term consequences, biomarkers of physiological effects as well as the psychological experiences are of significant importance for comprehensively understanding the complete COVID-19 recovery. The present research surveys the IgG antibody titers and the impact of COVID-19 as a traumatic experience in the aftermath of the active infection period, around 2 months after diagnosis, in a subset of COVID-19 patients from the first wave (March-April 2020) of the outbreak in Northern Cyprus. Associations of antibody titers and psychological survey measures with baseline characteristics and disease severity were explored, and correlations among various measures were evaluated. Of the 47 serology tests conducted for presence of IgG antibodies, 39 (83%) were positive. We identified trends demonstrating individuals experiencing severe or critical COVID-19 disease and/or those with comorbidities are more heavily impacted both physiologically and mentally, with higher IgG titers and negative psychological experience compared to those with milder disease and without comorbidities. We also observed that more than half of the COVID-19 cases had negative psychological experiences, being subjected to discrimination and verbal harassment/insult, by family/friends. In summary, as the first study co-evaluating immune response together with mental status in COVID-19, our findings suggest that further multidisciplinary research in larger sample populations as well as community intervention plans are needed to holistically address the physiological and psychological effects of COVID-19 among the cases.
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影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
11.8
作者：
Qin, Chuan;Zhou, Luoqi;Tian, Dai-Shi
通讯作者：
Tian, Dai-Shi
影响因子：
5.8
作者：
Hou, Hongyan;Wang, Ting;Sun, Ziyong
通讯作者：
Sun, Ziyong
DOI：
10.1093/jee/39.2.269
发表时间：
1945-01-01
期刊：
BIOMETRICS BULLETIN
影响因子：
--
作者：
WILCOXON, F
通讯作者：
WILCOXON, F
影响因子：
7.3
作者：
Diao, Bo;Wang, Chenhui;Chen, Yongwen
通讯作者：
Chen, Yongwen