Corticothalamic network dysfunction and Alzheimer's disease.
Corticothalamic network dysfunction and Alzheimer's disease.
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DOI：
10.1016/j.brainres.2017.09.014
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发表时间：
2019-01-01
期刊：
影响因子：
2.9
通讯作者：
Chin J
中科院分区：
文献类型：
--
作者：
Jagirdar R;Chin J
阿尔茨海默病（Alzheimer's disease，AD）是一种以进行性认知功能下降和脑电依赖性记忆显著丧失为特征的神经退行性疾病。因此，研究AD患者海马的功能和功能障碍成为研究的重点。然而，AD还伴随着许多其他使人衰弱的认知和行为改变，包括注意力、认知处理和睡眠维持方面的缺陷。在这些不同的行为领域中引起损伤的潜在机制尚不清楚，识别它们将有助于深入了解AD的多因素性质，并揭示潜在的新治疗靶点，以改善AD的整体功能。我们在这里提出的几条线的证据表明，皮质丘脑网络的失调可能是一个共同的分母，有助于在AD的各种认知和行为的改变。首先，我们将回顾这个网络调节过程的机制，包括注意力，认知加工，学习和记忆以及睡眠维持。然后，我们将审查这些行为和认知领域是如何改变AD。我们还将讨论如何在皮质丘脑网络中的严格调节的活动失调可以引起非惊厥性癫痫发作和其他形式的癫痫样活动，也已记录在AD患者和AD的转基因小鼠模型。总之，皮质丘脑网络有可能成为AD中受影响的各种认知和行为领域的主调节器。
Alzheimer’s disease (AD) is a devastating neurodegenerative disease that is characterized by progressive cognitive decline and a prominent loss of hippocampal-dependent memory. Therefore, much focus has been placed on understanding the function and dysfunction of the hippocampus in AD. However, AD is also accompanied by a number of other debilitating cognitive and behavioral alterations including deficits in attention, cognitive processing, and sleep maintenance. The underlying mechanisms that give rise to impairments in such diverse behavioral domains are unknown, and identifying them would shed insight into the multifactorial nature of AD as well as reveal potential new therapeutic targets to improve overall function in AD. We present here several lines of evidence that suggest that dysregulation of the corticothalamic network may be a common denominator that contributes to the diverse cognitive and behavioral alterations in AD. First, we will review the mechanisms by which this network regulates processes that include attention, cognitive processing, learning and memory, and sleep maintenance. Then we will review how these behavioral and cognitive domains are altered in AD. We will also discuss how dysregulation of tightly regulated activity in the corticothalamic network can give rise to non-convulsive seizures and other forms of epileptiform activity that have also been documented in both AD patients and transgenic mouse models of AD. In summary, the corticothalamic network has the potential to be a master regulator of diverse cognitive and behavioral domains that are affected in AD.
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影响因子：
82.9
作者：
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通讯作者：
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