The Fall of Sleep K-Complex in Alzheimer Disease.
The Fall of Sleep K-Complex in Alzheimer Disease.
复制标题
DOI：
10.1038/srep39688
复制
发表时间：
2017-01-03
影响因子：
4.6
通讯作者：
Rossini PM
中科院分区：
文献类型：
--
作者：
De Gennaro L;Gorgoni M;Reda F;Lauri G;Truglia I;Cordone S;Scarpelli S;Mangiaruga A;D'atri A;Lacidogna G;Ferrara M;Marra C;Rossini PM
虽然在阿尔茨海默病（AD）患者的觉醒和-在某种程度上-睡眠期间脑电图（EEG）活动的减缓（即，最近在健康老年人中的发现显示在NREM期间0.6-1 Hz慢波活动（SWA）降低，这与β-淀粉样蛋白沉积和受损的海马记忆巩固相关。我们推测，明显的矛盾可能是由0.6-1 Hz EEG活动和K复合波（KC）之间的部分重叠。根据这一观点，我们研究了20名AD患者和20名年龄匹配的健康对照者（HC）夜间睡眠时的额叶KC和SWA，假设KC比≤1 Hz SWA更好地区分患者和健康老年人。与HC相比，AD在第2阶段NREM期间KC密度急剧下降。患者显示KC密度降低超过40%，允许80%的正确分类。另一方面，与HC相比，AD患者的≤1 Hz SWA在大多数皮层区域中略高（不显著）。AD患者额区≤ 1Hz SWA无明显变化，但同一部位KC密度降低，且其降低与认知功能减退有关。
Although a slowing of electroencephalographic (EEG) activity during wakefulness and –to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6–1 Hz slow wave activity (SWA) during NREM, which was associated to β-amyloid deposition and impaired hippocampal memory consolidation. We hypothesize that the apparent contradiction may be explained by the partial overlap between 0.6–1 Hz EEG activity and K-Complex (KC). According to this view, we studied both frontal KCs and SWA in 20 AD patients and 20 healthy age-matched controls (HC) during nightly sleep, under the hypothesis that KCs better discriminate patients from healthy elderly than ≤1 Hz SWA. A drastic decrease of KC density during stage 2 NREM was found in AD compared to HC. Patients show more than 40% reduction of the KC density, allowing a correct classification of 80%. On the other hand, ≤1 Hz SWA of AD patients is slightly (not significantly) higher in most cortical areas compared to HC. Although no significant changes of ≤1 Hz SWA are detectable over frontal areas in AD, KC density decreases over the same location, and its decrease is related to the cognitive decline.
登录
查看更多内容
睡眠唤起的三角洲频率反应显示，整个成人寿命的振幅线性下降。
影响因子：
4.2
作者：
Colrain, Ian M.;Crowley, Kate E.;Nicholas, Christian L.;Afifi, Lamia;Baker, Fiona C.;Padilla, Mayra;Turlington, Sharon R.;Trinder, John
通讯作者：
Trinder, John
DOI：
10.1080/13803390490515540
发表时间：
2004-11-01
影响因子：
2.2
作者：
Chandler, MJ;Lacritz, LH;Cullum, CM
通讯作者：
Cullum, CM
影响因子：
4.7
作者：
Crowley, K;Trinder, J;Colrain, IM
通讯作者：
Colrain, IM
影响因子：
3.7
作者：
Amzica, F;Massimini, M
通讯作者：
Massimini, M
影响因子：
2.4
作者：
Bonanni, Enrica;Di Coscio, Elisa;Ktonas, Periklis Y.
通讯作者：
Ktonas, Periklis Y.