Effects of prenatal ethanol exposure on hippocampal ionotropic-quisqualate and kainate receptors.
Effects of prenatal ethanol exposure on hippocampal ionotropic-quisqualate and kainate receptors.
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产前乙醇暴露对海马离子型使君子氨酸和红藻氨酸受体的影响。
DOI：
10.1111/j.1530-0277.1992.tb00685.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Swartzwelder,HS
中科院分区：
文献类型：
--
作者：
Martin,D;Savage,DD;Swartzwelder,HS
我们实验室先前的研究表明，妊娠期间大鼠母体摄入适量乙醇可降低成年后代海马结构中N-甲基-d-天冬氨酸（NMDA）激动剂受体结合和NMDA介导的电生理反应。我们假设，产前乙醇暴露会对两种所谓的“非NMDA”谷氨酸受体亚型的受体数量和激动剂介导的反应产生相似的影响，这两种受体亚型是离子型使君子酸（RS）-α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯（AMPA）敏感性受体和红藻氨酸敏感性受体。Sprague-道利大鼠在整个妊娠期间自由采食含3.35%乙醇的流质饲料、等热量匹配的流质饲料或实验室饲料。在AMPA诱导或红藻氨酸诱导的海马CA 1锥体神经元去极化的激动剂浓度-反应曲线中，未观察到这三组后代之间的显著差异。此外，在背侧或腹侧海马结构的任何顶端树突区域中，未观察到组间[3 H]-AMPA或[3 H]-亚乙烯基红藻氨酸结合位点密度的显著差异。这些结果表明，离子型使君子酸和红藻氨酸受体，位于顶端树突状领域的主要海马神经元的区域，不受相同程度的产前乙醇暴露，这是已知的减少NMDA受体的结合和功能，在这些相同的区域。
Previous studies from our laboratories have shown that the consumption of moderate quantities of ethanol by rat dams during pregnancy reducesN‐methyl‐d‐aspartate (NMDA) agonist receptor binding and NMDA‐mediated electrophysiological responses in the hippocampal formation of adult offspring. We hypothesized that prenatal ethanol exposure would produce similar effects on receptor number and agonist‐mediated responses of two so‐called “non‐NMDA” subtypes of glutamate receptors, the ionotropic‐quisqualate (RS)‐α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate (AMPA)‐sensitive and the kainate‐sensitive receptors. Sprague‐Dawley rats were fed either a liquid diet containing 3.35% ethanol, an isocalorically matched liquid diet, or lab chow ad libitum throughout gestation. No significant differences between offspring from these three groups in the agonist concentration‐response curves for either AMPA‐induced or kainate‐induced depolarization of hippocampal CA1 pyramidal neurons were observed. Furthermore, no significant differences in the density of [3H]‐AMPA or [3H]‐vinylidene kainic acid binding sites in any of the apical dendritic field regions of dorsal or ventral hippocampal formation were observed between the groups. These results indicate that the ionotropic quisqualate and kainate receptors, located in the apical dendritic field regions of the principal hippocampal neurons, are not affected by the same degree of prenatal ethanol exposure, which is known to reduce NMDA receptor binding and function in these same regions.
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产前乙醇暴露会降低 45 日龄大鼠海马 NMDA 敏感的 [3H]-谷氨酸结合位点密度。
DOI：
10.1016/0741-8329(91)90806-8
发表时间：
1991
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Savage,DD;Montano,CY;Otero,MA;Paxton,LL
通讯作者：
Paxton,LL
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影响因子：
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作者：
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通讯作者：
C. Cotman
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影响因子：
3.5
作者：
W. Fleming;D. Westfall;I. S. de la Lande;L. Jellett
通讯作者：
L. Jellett
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影响因子：
2.5
作者：
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通讯作者：
I. Morgan
影响因子：
2.9
作者：
A. Streissguth;F. Bookstein;P. Sampson;H. Barr
通讯作者：
A. Streissguth;F. Bookstein;P. Sampson;H. Barr