Histoplasma Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen.
Histoplasma Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen.
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DOI：
10.1093/ofid/ofad510
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发表时间：
2023-10
影响因子：
4.2
通讯作者：
Scantlebury, Claire Elizabeth
中科院分区：
文献类型：
--
作者：
Cornell, Tessa R.;Jobe, Dawda;Donkor, Simon;Wootton, Daniel G.;Pinchbeck, Gina;Sutherland, Jayne S.;Scantlebury, Claire Elizabeth
将组织浆体列入世界卫生组织第一份真菌优先病原体清单，在“高优先”真菌物种下，突出了在流行和代表性不足地区对组织浆体进行强有力监测的必要性。尽管非洲组织胞浆菌病的报告越来越多，但冈比亚关于这种真菌疾病负担的数据很少。本基线研究检测了冈比亚一结核患者人群中抗组织浆体抗体的血清阳性率，探讨了血清阳性率与人口统计学和临床变量之间的关系，并提出了未来的研究方向。生物库血浆样本选自不同HIV感染状态的活动性结核病例。对来自52个研究参与者的样本进行乳胶凝集试验，以检测抗组织浆体抗体的存在。采用logistic回归分析探讨组织浆体暴露的潜在危险因素。血清抗组织浆体抗体阳性率为28.8% （n = 15/52; 95% CI, 17.1% ~ 43.1%）。多变量logistic回归分析发现，组织浆体血清阳性与年龄之间存在统计学显著相关（优势比0.91;95% CI, 0.84-0.98; P = 0.008）。这项基线研究提供了冈比亚结核病患者组织浆体血清阳性的证据，并探讨了暴露的危险因素。小样本量和LAT在结核病和艾滋病毒阳性患者群体中的使用是研究的重大局限性。未来的研究方向是确定组织浆体在一般人群和患者群体中的负担，并探索冈比亚暴露和感染的特定环境风险因素。
Inclusion of Histoplasma in the World Health Organization's first Fungal Priority Pathogens List under “high-priority” fungal species highlights the need for robust surveillance of Histoplasma spp. in endemic and underrepresented regions. Despite increasing reports of histoplasmosis in Africa, data on the burden of this fungal disease are sparse in The Gambia. This baseline study examined the human seroprevalence of anti-Histoplasma antibody in a TB patient group in The Gambia, explored associations between seropositivity and demographic and clinical variables, and proposes future research directions. Biobanked plasma samples were selected from active TB cases with variable HIV infection status. Latex agglutination tests were performed on samples from 52 study participants to detect the presence of anti-Histoplasma antibodies. Potential risk factors for Histoplasma exposure were explored using logistic regression analysis. The sample seroprevalence of anti-Histoplasma antibody was 28.8% (n = 15/52; 95% CI, 17.1%–43.1%). Multivariable logistic regression analysis identified a statistically significant association between Histoplasma seropositivity and age (odds ratio, 0.91; 95% CI, 0.84–0.98; P = .008). This baseline study provides evidence of Histoplasma seropositivity in TB patients in The Gambia and explores risk factors for exposure. The small sample size and use of the LAT in TB and HIV-positive patient groups are significant study limitations. Future research directions are proposed to ascertain the burden of Histoplasma in general and patient populations and explore the context-specific risk factors for exposure and infection in The Gambia.
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影响因子：
4.7
作者：
Ekeng, Bassey E.;Davies, Adeyinka A.;Osaigbovo, Iriagbonse I.;Warris, Adilia;Oladele, Rita O.;Denning, David W.
通讯作者：
Denning, David W.
影响因子：
4.2
作者：
通讯作者：
--
影响因子：
3.8
作者：
Nacher M;Adenis A;Sambourg E;Huber F;Abboud P;Epelboin L;Mosnier E;Vantilcke V;Dufour J;Djossou F;Demar M;Couppié P
通讯作者：
Couppié P
DOI：
10.1007/bf02051586
发表时间：
1962-01-01
期刊：
MYCOPATHOL ET MYCOL APPL
影响因子：
--
作者：
HILL, GRACE B.;CAMPBELL, CHARLOTTE C.
通讯作者：
CAMPBELL, CHARLOTTE C.
影响因子：
3.6
作者：
Diadie, S.;Diatta, B.;Dieng, M. T.
通讯作者：
Dieng, M. T.