Taurine Reverses Atrial Structural Remodeling in Ach-Cacl2 Induced Atrial Fibrillation Rats.
Taurine Reverses Atrial Structural Remodeling in Ach-Cacl2 Induced Atrial Fibrillation Rats.
复制标题
牛磺酸逆转 Ach-Cacl2 诱导的心房颤动大鼠的心房结构重塑。
DOI：
10.1007/978-94-024-1079-2_65
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
胡建民
中科院分区：
文献类型：
--
作者：
杨群辉;吴高峰;汉丽梅;冯颖;林树梅;吕秋凤;杨建成;胡建民
据报道牛磺酸具有抗心律失常作用，但抗心房颤动（AF）的作用及其机制仍未完全明确。在本研究中，对治疗效果及部分机制进行了研究。心房颤动动物模型……
Taurine has been reported to have anti-arrhythmia effects, but the anti-atrial fibrillation (AF) effects and its mechanism remain incompletely understood. In the present study, the therapy effects and partly mechanisms were investigated. AF animal model was established by intravenous administered with the mixture of acetylcholine (Ach) and CaCl2(66 μg/mL + 10 mg/mL) (i.v.) for 7 days. The actions of taurine (99 mg/kg∙d, introgastric administration) on the levels of Hs-CRP, IL-6, TNF-α, MMP-9, AngII, the extent of the fibrosis and ultrastructural changes in left atrial were studied. The data showed that the serum levels of TNF-α, IL-6, AngII and the plasma levels of Hs-CRP and MMP-9 were significantly elevated in automatic recovery group relative to the control group (p < 0.01), which were all decreased by taurine administration (p < 0.01) similar to Verapamil treatment. Masson's trichrome staining of the left atrial tissue showed an obvious interstitial fibrosis in rats of automatic recovery group. The alteration could be reversed by additional taurine. Electron microscopy revealed that taurine administration could significantly alleviate the ultrastructural damage of atrial cells, and the effects were similar to the Verapamil treatment. In conclusion, the results suggested that taurine could inhibit the structural remodeling of AF in rats partly by decreasing the levels of inflammatory factors and profibrotic molecules, attenuating the extent of myocardial fibrosis and protecting the integrity of myocardial ultrastructure.
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影响因子：
5.6
作者：
G. Schuller-Levis;R. Gordon;Chuanhua Wang;Seung-Yong Park;E. Park
通讯作者：
G. Schuller-Levis;R. Gordon;Chuanhua Wang;Seung-Yong Park;E. Park
血管紧张素 II 诱导炎症导致心脏重塑
影响因子：
3.1
作者：
Jia, Lixin;Li, Yulin;Du, Jie
通讯作者：
Du, Jie
DOI：
--
发表时间：
1963-03
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
W. Read;J. Welty
通讯作者：
W. Read;J. Welty
影响因子：
4.8
作者：
Balasubramanian, Sujata;Fan, Meiyun;Vestal, Deborah J.
通讯作者：
Vestal, Deborah J.
影响因子：
2.8
作者：
Gu J;Hu W;Liu X
通讯作者：
Liu X