Decreased frontal N-acetylaspartate levels in adolescents concurrently using both methamphetamine and marijuana.
Decreased frontal N-acetylaspartate levels in adolescents concurrently using both methamphetamine and marijuana.
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DOI：
10.1016/j.bbr.2013.02.028
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发表时间：
2013-06-01
影响因子：
2.7
通讯作者：
Yurgelun-Todd, Deborah A.
中科院分区：
文献类型：
--
作者：
Sung, Young-Hoon;Carey, Paul D.;Stein, Dan J.;Ferrett, Helen L.;Spottiswoode, Bruce S.;Renshaw, Perry F.;Yurgelun-Todd, Deborah A.
与使用甲基苯丙胺 (MA) 或大麻 (MJ) 对发育中的青少年大脑相关的潜在神经化学毒性尚不清楚，特别是对于同时使用 MA 和 MJ (MA+MJ) 的个体。在这项研究中，利用质子磁共振波谱 (MRS) 测量体内大脑 N-乙酰天冬氨酸和 N-乙酰天冬氨酰谷氨酸（tNAA，完整神经元完整性的指标）水平。来自南非开普敦的三个青少年群体完成了 MRS 扫描以及包括吸毒史在内的临床测量。受试者包括 (1) 9 名 MA（年龄 = 15.7 ± 1.37）、(2) 8 名使用青少年的 MA+MJ（年龄 = 16.2 ± 1.16）和 (3) 10 名健康对照（年龄 = 16.8 ± 0.62）。使用点分辨光谱序列（PRESS）从中额叶灰质获取单体素光谱。 MRS 数据采用全自动方法进行后处理，用于定量磷酸肌酸加肌酸 (PCr+Cr) 的代谢物比率。与健康对照组（p = 0.01，降低 7.2%）和 MA 组（p = 0.04，降低 6.9%）相比，MA+MJ 组的额叶 tNAA/PCr+Cr 比率显着降低。仅在 MA+MJ 组中，tNAA/PCr+Cr 比率下降与 MA 或 MJ 用药史（总累积终生剂量、发病年龄、MA 和 MJ 暴露持续时间）之间也观察到显着关系（所有 p < 0.05）。这些发现表明，在青少年中，同时大量使用 MA+MJ 可能会导致额叶灰质中大脑代谢的改变。异常的 tNAA/PCr+Cr 比值与药物使用史之间的显着相关性表明，MA+MJ 滥用可能会以剂量反应的方式在青少年大脑中诱导神经毒性。
The potential neurochemical toxicity associated with methamphetamine (MA) or marijuana (MJ) use on the developing adolescent brain is unclear, particularly with regard to individuals with concomitant use of MA and MJ (MA+MJ). In this study, proton magnetic resonance spectroscopy (MRS) was utilized to measure in vivo brain N-acetylaspartate plus N-acetylaspartyl glutamate (tNAA, an indicator of intact neuronal integrity) levels. Three adolescent groups from Cape Town, South Africa completed MRS scans as well as clinical measures including a drug use history. Subjects included (1) nine MA (age = 15.7 ± 1.37), (2) eight MA+MJ (age = 16.2 ± 1.16) using adolescents and (3) ten healthy controls (age = 16.8 ± 0.62). Single voxel spectra were acquired from midfrontal gray matter using a point-resolved spectroscopy sequence (PRESS). The MRS data were post-processed in the fully automated approach for quantitation of metabolite ratios to phosphocreatine plus creatine (PCr+Cr). A significant reduction in frontal tNAA/PCr+Cr ratios was seen in the MA+MJ group compared to the healthy controls (p = 0.01, by 7.2 %) and to the MA group (p = 0.04, by 6.9 %). Significant relationships were also observed between decreased tNAA/PCr+Cr ratios and drug use history of MA or MJ (total cumulative lifetime dose, age of onset, and duration of MA and MJ exposure) only in the MA+MJ group (all p < 0.05). These findings suggest that in adolescents, concomitant heavy MA+MJ use may contribute to altered brain metabolites in frontal gray matter. The significant associations between the abnormal tNAA/PCr+Cr ratios and the drug use history suggest that MA+MJ abuse may induce neurotoxicity in a dose-responsive manner in adolescent brain.
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影响因子：
5.5
作者：
Crean RD;Crane NA;Mason BJ
通讯作者：
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影响因子：
3.4
作者：
Curran, HV;Brignell, C;Henry, J
通讯作者：
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DOI：
10.2174/156800705774322111
发表时间：
2005-10-01
期刊：
Current Drug Targets - CNS and Neurological Disorders
影响因子：
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作者：
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通讯作者：
Grotenhermen, Franjo
影响因子：
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作者：
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影响因子：
19.7
作者：
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通讯作者：
Metreweli, C