Structure/function interrelationships and illness insight in patients with schizophrenia: a multimodal MRI data fusion study.
Structure/function interrelationships and illness insight in patients with schizophrenia: a multimodal MRI data fusion study.
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精神分裂症患者的结构/功能相互关系和疾病洞察：多模态 MRI 数据融合研究。
DOI：
10.1007/s00406-023-01566-1
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发表时间：
2023-12
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
精神分裂症(SZ)的疾病洞察力对治疗结果、融入社会有重要影响，并可能在精神障碍的过程中有所不同。为了处理和治疗疾病洞察力减少或缺失，我们需要更好地了解其功能和结构上的相关性。之前的研究表明，与认知控制和自我参照相关的大脑区域的大脑体积出现区域性异常。然而，对SZ患者的疾病洞察力与结构和功能网络强度之间的关联知之甚少。本研究采用横断面设计，采用结构和静息状态功能磁共振成像技术，研究SZ患者(n = 74例)和健康对照组(n = 47例)的结构和功能差异。对结构数据进行基于体素的形态测量，并计算功能数据的低频波动幅度(Alff)。为了研究结构/功能异常的相互关系及其与疾病洞察力的关系，我们使用了平行独立成分分析(PICA)。两组(SZ和HC)在不同的结构和功能网络中发现了显著的差异，主要包括额顶叶、颞叶和小脑区域。在疾病洞察力和两个不同的结构网络之间发现了显著的关联，这两个结构网络包括额叶(中央前回和中央后回、顶下小叶、丘脑和楔前叶)和后皮质区域(楔叶、楔前叶、舌叶、扣带后回和枕中回)。最后，我们发现疾病洞察力与由颞区(颞上回)组成的功能网络之间存在显著的关系。这项研究表明，在深圳，附属于认知控制、记忆和自我参照的神经系统的异常结构和功能完整性与疾病洞察力密切相关。网上版载有补充材料，可在10.1007/s00406-023-01566-1查阅。
Illness insight in schizophrenia (SZ) has an important impact on treatment outcome, integration into society and can vary over the course of the disorder. To deal with and treat reduced or absent illness insight, we need to better understand its functional and structural correlates. Previous studies showed regionally abnormal brain volume in brain areas related to cognitive control and self-reference. However, little is known about associations between illness insight and structural and functional network strength in patients with SZ. This study employed a cross-sectional design to examine structural and functional differences between patients with SZ (n = 74) and healthy controls (n = 47) using structural and resting-state functional magnetic resonance imaging (MRI). Voxel-based morphometry was performed on structural data, and the amplitude of low frequency fluctuations (ALFF) was calculated for functional data. To investigate abnormal structure/function interrelationships and their association with illness insight, we used parallel independent component analysis (pICA). Significant group (SZ vs. HC) differences were detected in distinct structural and functional networks, predominantly comprising frontoparietal, temporal and cerebellar regions. Significant associations were found between illness insight and two distinct structural networks comprising frontoparietal (pre- and postcentral gyrus, inferior parietal lobule, thalamus, and precuneus) and posterior cortical regions (cuneus, precuneus, lingual, posterior cingulate, and middle occipital gyrus). Finally, we found a significant relationship between illness insight and functional network comprising temporal regions (superior temporal gyrus). This study suggests that aberrant structural and functional integrity of neural systems subserving cognitive control, memory and self-reference are tightly coupled to illness insight in SZ. The online version contains supplementary material available at 10.1007/s00406-023-01566-1.
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影响因子：
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