The role of 5-HTT LPR and GNβ3 825C>T polymorphisms and gene-environment interactions in irritable bowel syndrome (IBS).
The role of 5-HTT LPR and GNβ3 825C>T polymorphisms and gene-environment interactions in irritable bowel syndrome (IBS).
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DOI：
10.1007/s10620-012-2319-9
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发表时间：
2012-10
影响因子：
3.1
通讯作者：
Talley, Nicholas J.
中科院分区：
文献类型：
--
作者：
Saito, Yuri A.;Larson, Joseph J.;Atkinson, Elizabeth J.;Ryu, Euijung;Almazar, Ann E.;Petersen, Gloria M.;Talley, Nicholas J.
较小的研究已经评估了肠易激综合征中SLC6A4 5-HTTLPR和GNβ3 825C>T多态性，并且在精神病学文献中报道了5- htlpr与生活事件之间的相互作用，但缺乏肠易激综合征的基因环境研究。评估两种多态性与肠易激综合征和发病年龄的关系；并评估肠易激综合症是否存在基因-环境相互作用。肠易激综合征门诊患者和对照组患者完成了一份有效的问卷调查，并提供了DNA血样。采用logistic回归对病例和对照组的基因型/等位基因频率进行比较。线性回归用于评估变异与发病年龄之间的关系。测试的环境变量包括虐待、父母酗酒、父母精神疾病和胃肠道感染。对385例病例和262例对照进行了基因分型，其中年龄中位数为50岁（范围18.0-70.0），女性498例（77%）。d型IBS 102例（26%），c型IBS 40例（10%），m型IBS 125例（32%），其他型118例（31%）。没有观察到IBS或发病年龄与这两种变异之间的关联。胃肠道感染与GNβ3 825T等位基因之间存在显著的相互作用。对于那些报告有胃肠道感染的患者，IBS的OR为3.9 (95%CI: 1.2-12.7)，而对于那些之前没有感染的患者，OR为0.86 （95%CI: 0.65-1.13）。在IBS的发展过程中，GNβ3多态性与感染之间存在显著的相互作用，提示其病因是特定遗传和环境危险因素共同作用的结果。
Smaller studies have evaluated SLC6A4 5-HTTLPR and GNβ3 825C>T polymorphisms in IBS, and interactions between 5-HTT LPR with life events have been reported in the psychiatric literature, but gene-environment studies in IBS are lacking. To assess the association of two polymorphisms with IBS and age of onset; and to assess whether there are gene-environment interactions with IBS. Outpatients with IBS and controls completed a validated questionnaire and provided blood for DNA. Comparisons of genotype/allele frequencies between cases and controls were performed with logistic regression. Linear regression was used to evaluate the association between the variants and age of onset. Environmental variables tested included abuse, parental alcohol abuse, parental psychiatric disorders, and gastrointestinal infections. Genotyping was performed in 385 cases and 262 controls with median age of 50 yrs (range: 18.0–70.0) and 498 (77%) females. The IBS subtype distribution among cases was: 102 (26%) D-IBS, 40 (10%) C-IBS, 125 (32%) M-IBS, 118 (31%) other. No association was observed between IBS or age of onset and both variants. Significant interactions were observed between GI infection and the GNβ3 825T allele. For those reporting gastrointestinal infection, the OR for IBS was 3.9 (95%CI: 1.2–12.7) whereas the OR was 0.86 (95% CI: 0.65–1.13) for those without prior infection. There was a significant interaction between the GNβ3 polymorphism and infection in the development of IBS, suggesting that its etiology is the result of a combination of specific genetic and environmental risk factors.
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影响因子：
29.4
作者：
Andresen, Viola;Camilleri, Michael;Zinsmeister, Alan R.
通讯作者：
Zinsmeister, Alan R.
影响因子：
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作者：
Rosskopf, D;Busch, S;Siffert, W
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Siffert, W
影响因子：
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作者：
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Trudgill, NJ
影响因子：
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作者：
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通讯作者：
Tsuang, MT
影响因子：
9.8
作者：
Camilleri, CE;Carlson, PJ;Urrutia, R
通讯作者：
Urrutia, R