Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta-analysis from eight cohort studies.
Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta-analysis from eight cohort studies.
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DOI：
10.1111/1471-0528.15476
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Ong KK
中科院分区：
文献类型：
--
作者：
Pastorino S;Bishop T;Crozier SR;Granström C;Kordas K;Küpers LK;O'Brien EC;Polanska K;Sauder KA;Zafarmand MH;Wilson RC;Agyemang C;Burton PR;Cooper C;Corpeleijn E;Dabelea D;Hanke W;Inskip HM;McAuliffe FM;Olsen SF;Vrijkotte TG;Brage S;Kennedy A;O'Gorman D;Scherer P;Wijndaele K;Wareham NJ;Desoye G;Ong KK
关于怀孕期间休闲时间身体活动（LTPA）对出生体重影响的证据并不一致。我们的目的是研究妊娠早期和晚期LTPA与新生儿人体测量结果之间的关系。个体水平的Meta分析，减少了研究间的异质性。一个由8项基于人群的研究（7项欧洲研究和1项美国研究）组成的联盟，包括72694例受试者。使用包含混杂因素（胎龄、性别、产次、母亲年龄、教育、种族、BMI、吸烟和饮酒）的广义线性模型来检验妊娠早期（8-18周）或妊娠晚期（30周以上）自我报告的LTPA与结局之间的相关性。使用随机效应Meta分析汇总结果。出生体重、大于胎龄儿（LGA）、巨大儿、小于胎龄儿（SGA）、%体脂和出生体重指数。晚期，但不是早期，妊娠母亲中度到剧烈的体力活动（MVPA），剧烈活动，和LTPA能量消耗与BW，LGA，巨大儿，和体重指数呈中度负相关，没有异质性（所有：I2 = 0%）。MVPA每增加1小时/周，LGA和巨大儿的RR分别为0.97（95% CI：0.96，0.98）和0.96（95% CI：0.94，0.98）。在对母亲BMI和妊娠期糖尿病进行额外调整后，相关性仅略有降低。LTPA的测量与SGA的风险无关。妊娠晚期而非妊娠早期的体力活动与LGA和巨大儿的风险适度降低相关，但与SGA无关。在一项个体参与者Meta分析中，妊娠晚期中度至剧烈的体力活动适度降低了出生体重结局。在一项个体参与者Meta分析中，妊娠晚期中度至剧烈的体力活动适度降低了出生体重结局。
Evidence on the impact of leisure time physical activity (LTPA) in pregnancy on birth size is inconsistent. We aimed to examine the association between LTPA during early and late pregnancy and newborn anthropometric outcomes. Individual level meta‐analysis, which reduces heterogeneity across studies. A consortium of eight population‐based studies (seven European and one US) comprising 72 694 participants. Generalised linear models with consistent inclusion of confounders (gestational age, sex, parity, maternal age, education, ethnicity, BMI, smoking, and alcohol intake) were used to test associations between self‐reported LTPA at either early (8–18 weeks gestation) or late pregnancy (30+ weeks) and the outcomes. Results were pooled using random effects meta‐analyses. Birth weight, large‐for‐gestational age (LGA), macrosomia, small‐for‐gestational age (SGA), % body fat, and ponderal index at birth. Late, but not early, gestation maternal moderate to vigorous physical activity (MVPA), vigorous activity, and LTPA energy expenditure were modestly inversely associated with BW, LGA, macrosomia, and ponderal index, without heterogeneity (all: I 2 = 0%). For each extra hour/week of MVPA, RR for LGA and macrosomia were 0.97 (95% CI: 0.96, 0.98) and 0.96 (95% CI: 0.94, 0.98), respectively. Associations were only modestly reduced after additional adjustments for maternal BMI and gestational diabetes. No measure of LTPA was associated with risk for SGA. Physical activity in late, but not early, pregnancy is consistently associated with modestly lower risk of LGA and macrosomia, but not SGA. In an individual participant meta‐analysis, late pregnancy moderate to vigorous physical activity modestly reduced birth size outcomes. In an individual participant meta‐analysis, late pregnancy moderate to vigorous physical activity modestly reduced birth size outcomes.
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影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
DOI：
10.1097/00005768-199610000-00012
发表时间：
1996-10-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Durante, R;Ainsworth, BE
通讯作者：
Ainsworth, BE
影响因子：
3.3
作者：
BONEN, A;CAMPAGNA, P;BERESFORD, P
通讯作者：
BERESFORD, P
影响因子：
9.8
作者：
Clapp, JF;Kim, H;Lopez, B
通讯作者：
Lopez, B
影响因子：
8.2
作者：
Dipla, Konstantina;Triantafyllou, Areti;Goulis, Dimitrios G.
通讯作者：
Goulis, Dimitrios G.