Environmental determinants of allergy and asthma in early life.
Environmental determinants of allergy and asthma in early life.
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DOI：
10.1016/j.jaci.2017.05.010
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Hernandez ML
中科院分区：
文献类型：
--
作者：
Burbank AJ;Sood AK;Kesic MJ;Peden DB;Hernandez ML
近几十年来，过敏性疾病的患病率显著增加。一级预防工作的指导是对产前阶段开始的集体环境暴露的研究，以确定影响过敏性疾病风险的可改变因素。在这篇综述中，我们探讨了支持产前和生命早期外部干扰素组的关键组成部分及其对特应性发育的影响之间关系的证据，重点是微生物，过敏原和空气污染暴露。在生命的最初几个月和几年中微生物暴露的丰富性和多样性与过敏性致敏和疾病的风险有关。在生命早期的室内环境过敏原暴露也可能影响疾病的发展，这取决于过敏原的类型，剂量和暴露的时间。最近的证据支持环境空气污染在过敏性疾病发病中的作用。缺乏明确的文献环境和特应性之间的关系，反映了复杂的相互作用之间的累积环境因素和遗传易感性，没有一个因素决定疾病的发展在所有的个人。需要了解儿童发育过程中环境暴露总和的影响，以确定降低儿童特应性风险的具有成本效益的干预措施。
Allergic disease prevalence has significantly increased in recent decades. Primary prevention efforts are being guided by the study of the exposome, or collective environmental exposures beginning during the prenatal period, to identify modifiable factors that impact allergic disease risk. In this review, we explore the evidence supporting a relationship between key components of the external exposome in the prenatal and early-life periods and their impact on atopy development, focused on microbial, allergen, and air pollution exposures. The abundance and diversity of microbial exposures during the first months and years of life have been linked with risk of allergic sensitization and disease. Indoor environmental allergen exposure during early life may also impact disease development, depending on the allergen type, dose, and timing of exposure. Recent evidence supports the role of ambient air pollution in allergic disease inception. The lack of clarity in the literature surrounding the relationship between environment and atopy reflects the complex interplay between cumulative environmental factors and genetic susceptibility, such that no one factor dictates disease development in all individuals. Understanding the impact of the summation of environmental exposures throughout a child's development is needed to identify cost-effective interventions that reduce atopy risk in children.
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影响因子：
3.7
作者：
Lødrup Carlsen KC;Roll S;Carlsen KH;Mowinckel P;Wijga AH;Brunekreef B;Torrent M;Roberts G;Arshad SH;Kull I;Krämer U;von Berg A;Eller E;Høst A;Kuehni C;Spycher B;Sunyer J;Chen CM;Reich A;Asarnoj A;Puig C;Herbarth O;Mahachie John JM;Van Steen K;Willich SN;Wahn U;Lau S;Keil T;GALEN WP 1.5 ‘Birth Cohorts’ working group
通讯作者：
GALEN WP 1.5 ‘Birth Cohorts’ working group
影响因子：
14.2
作者：
Celedon, Juan C.;Milton, Donald K.;Gold, Diane R.
通讯作者：
Gold, Diane R.
影响因子：
12.4
作者：
Casas, L.;Sunyer, J.;Torrent, M.
通讯作者：
Torrent, M.
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
影响因子：
5.9
作者：
Carter, PM;Peterson, EL;Johnson, CC
通讯作者：
Johnson, CC