Tumor Protein p63/microRNA Network in Epithelial Cancer Cells.
Tumor Protein p63/microRNA Network in Epithelial Cancer Cells.
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DOI：
10.2174/13892029113146660011
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发表时间：
2013-11
期刊：
影响因子：
2.6
通讯作者：
Ratovitski EA
中科院分区：
文献类型：
--
作者：
Ratovitski EA
非编码microrna参与了癌细胞对应激反应的多种调控机制，导致细胞凋亡、细胞周期阻滞和自噬。许多分子层参与细胞反应，包括表观遗传调控转录，RNA加工，代谢，信号传导。肿瘤蛋白(TP)-p53家族成员与特异性microrna之间的分子相互关系是支持肿瘤细胞对化疗反应的关键功能网络，并可能在人类上皮癌的化疗耐药中发挥决定性作用。研究表明，TP63可以调节多种microrna的表达，这些microrna参与多种上皮细胞癌（如鳞状细胞癌、卵巢癌、前列腺癌、胃癌、膀胱癌和乳腺癌）中上皮细胞增殖、分化、衰老、“干性”和皮肤维持、上皮/间充质转化和肿瘤发生的调节，以及癌细胞的化疗耐药。TP63/microRNA网络参与了细胞周期阻滞、凋亡、自噬、代谢和表观遗传转录调控，从而为新的化疗场所提供了基础。
Non-coding microRNAs are involved in multiple regulatory mechanisms underlying response of cancer cells to stress leading to apoptosis, cell cycle arrest and autophagy. Many molecular layers are implicated in such cellular response including epigenetic regulation of transcription, RNA processing, metabolism, signaling. The molecular interrelationship between tumor protein (TP)-p53 family members and specific microRNAs is a key functional network supporting tumor cell response to chemotherapy and potentially playing a decisive role in chemoresistance of human epithelial cancers. TP63 was shown to modulate the expression of numerous microRNAs involved in regulation of epithelial cell proliferation, differentiation, senescence, “stemness” and skin maintenance, epithelial/ mesenchymal transition, and tumorigenesis in several types of epithelial cancers (e.g. squamous cell carcinoma, ovarian carcinoma, prostate carcinoma, gastric cancer, bladder cancer, and breast tumors), as well as in chemoresistance of cancer cells. TP63/microRNA network was shown to be involved in cell cycle arrest, apoptosis, autophagy, metabolism and epigenetic transcriptional regulation, thereby providing the groundwork for novel chemotherapeutic venues.
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影响因子：
12.3
作者：
Galasso M;Sana ME;Volinia S
通讯作者：
Volinia S
MiR-26a 通过抑制 MCL-1 抑制乳腺癌的增殖和迁移。
影响因子：
3.7
作者：
Gao J;Li L;Wu M;Liu M;Xie X;Guo J;Tang H;Xie X
通讯作者：
Xie X
影响因子：
--
作者：
Bergholz, Johann;Xiao, Zhi-Xiong
通讯作者：
Xiao, Zhi-Xiong
DOI：
10.1073/pnas.1112257109
发表时间：
2012-01-24
影响因子：
11.1
作者：
Cervo, Pia Rivetti di Val;Lena, Anna Maria;Melino, Gerry
通讯作者：
Melino, Gerry
影响因子：
48
作者：
Ebert, Margaret S.;Neilson, Joel R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.