MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1.
MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1.
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MiR-26a 通过抑制 MCL-1 抑制乳腺癌的增殖和迁移。
DOI：
10.1371/journal.pone.0065138
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Gao J;Li L;Wu M;Liu M;Xie X;Guo J;Tang H;Xie X
乳腺癌是女性中最常见的恶性肿瘤。MicroRNAs是一类长度为18-25个核苷酸的非编码小rna，可在转录后调节基因表达。MiR-26a已被报道为乳腺癌中的肿瘤抑制microRNA，其主要作用是靶向MTDH和EZH2，然而，MiR-26a的表达谱和治疗潜力尚不清楚。本研究证明miR-26a在乳腺癌细胞和临床标本中下调，其在乳腺癌细胞中的调节调节细胞增殖、集落形成、迁移和凋亡。MCL-1是Bcl-2家族的抗凋亡成员，作为miR-26a的新靶点，被发现与miR-26a的异位表达呈负相关，MCL-1的下调可表型化miR-26a在乳腺癌细胞系中的作用。进一步探讨miR-26a增加乳腺癌细胞对MCL-1参与的紫杉醇的敏感性。因此，miR-26a通过调节几种与癌变相关的过程，包括一种涉及靶向MCL-1的新机制，影响乳腺癌的细胞增殖和迁移。
Breast cancer is the most commonly malignancies in women. MicroRNAs are a family of small non-coding RNAs 18–25 nucleotides in length that post-transcriptionally modulate gene expression. MiR-26a has been reported as a tumor suppressor microRNA in breast cancer, which is attributed mainly to targeting of MTDH and EZH2, however, the expression profile and therapeutic potential of miR-26a is still unclear. Here we demonstrate that miR-26a is down-regulated in breast cancer cells and clinical specimens and its modulation in breast cancer cells regulates cell proliferation, colony formation, migration and apoptosis. MCL-1, an anti-apoptotic member of the Bcl-2 family, as novel targets of miR-26a was found to be in reverse correlation with ectopic expression of miR-26a and knockdown of MCL-1 phenocopied the effect of miR-26a in breast cancer cell lines. It was further explored that miR-26a increased sensitivity of breast cancer cells to paclitaxel in which MCL-1 was involved. Thus, miR-26a impacts on cell proliferation and migration of breast cancer by regulating several carcinogenesis-related processes, including a novel mechanism involving the targeting of MCL-1.
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影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
影响因子：
51.1
作者：
Entschladen, F;Drell, TL;Zaenker, KS
通讯作者：
Zaenker, KS
影响因子：
11.2
作者：
Iorio, MV;Ferracin, M;Croce, CM
通讯作者：
Croce, CM
DOI：
10.1056/nejmoa0901282
发表时间：
2009-10-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ji J;Shi J;Budhu A;Yu Z;Forgues M;Roessler S;Ambs S;Chen Y;Meltzer PS;Croce CM;Qin LX;Man K;Lo CM;Lee J;Ng IO;Fan J;Tang ZY;Sun HC;Wang XW
通讯作者：
Wang XW
影响因子：
10.5
作者：
Huse, Jason T.;Brennan, Cameron;Holland, Eric C.
通讯作者：
Holland, Eric C.