The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study.
The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study.
复制标题
DOI：
10.1289/ehp.7187
复制
发表时间：
2004-10
影响因子：
10.4
通讯作者：
Hägerhed-Engman L
中科院分区：
文献类型：
--
作者：
Bornehag CG;Sundell J;Weschler CJ;Sigsgaard T;Lundgren B;Hasselgren M;Hägerhed-Engman L
全球邻苯二甲酸酯产量已从第二次世界大战结束时的极低水平增加到大约350万吨/年。本研究的目的是调查儿童的持续性过敏症状与他们家中收集的粉尘中邻苯二甲酸盐浓度之间的潜在联系。在过去30年里，发达国家的儿童过敏症状显著增加。这项调查是一项嵌套在10852名儿童队列中的病例对照研究。从队列中，我们选择了198例有持续性过敏症状的患者和202例没有过敏症状的对照组。一个临床和技术团队对每个孩子和她或他的环境进行了调查。我们发现，病例组粉尘中邻苯二甲酸丁基苄酯(BBZP)的中位数浓度(0.15 mg/g粉尘)高于对照组(0.12 mg/g粉尘)。按症状分组分析，BBZP与鼻炎(P=0.001)和湿疹(P=0.001)有关，而邻苯二甲酸二(2-乙基己基)酯与哮喘(P=0.022)有关。此外，趋势分析支持这些关联的剂量-反应关系。这项研究表明，邻苯二甲酸盐，在室内环境中通常发现的范围内，与儿童的过敏症状有关。我们认为，三种主要邻苯二甲酸酯-BBZP、DEHP和邻苯二甲酸二丁酯-的不同症状关联可以通过化学物理特性和毒理学潜力的组合来解释。考虑到全球儿童接触邻苯二甲酸盐的情况，这项针对瑞典儿童的研究结果具有全球影响。
Global phthalate ester production has increased from very low levels at the end of World War II to approximately 3.5 million metric tons/year. The aim of the present study was to investigate potential associations between persistent allergic symptoms in children, which have increased markedly in developed countries over the past three decades, and the concentration of phthalates in dust collected from their homes. This investigation is a case–control study nested within a cohort of 10,852 children. From the cohort, we selected 198 cases with persistent allergic symptoms and 202 controls without allergic symptoms. A clinical and a technical team investigated each child and her or his environment. We found higher median concentrations of butyl benzyl phthalate (BBzP) in dust among cases than among controls (0.15 vs. 0.12 mg/g dust). Analyzing the case group by symptoms showed that BBzP was associated with rhinitis (p = 0.001) and eczema (p = 0.001), whereas di(2-ethylhexyl) phthalate (DEHP) was associated with asthma (p = 0.022). Furthermore, dose–response relationships for these associations are supported by trend analyses. This study shows that phthalates, within the range of what is normally found in indoor environments, are associated with allergic symptoms in children. We believe that the different associations of symptoms for the three major phthalates—BBzP, DEHP, and di-n-butyl phthalate—can be explained by a combination of chemical physical properties and toxicologic potential. Given the phthalate exposures of children worldwide, the results from this study of Swedish children have global implications.
登录
查看更多内容
影响因子：
4.5
作者：
Larsen, ST;Hansen, JS;Nielsen, GD
通讯作者：
Nielsen, GD
影响因子：
4.1
作者：
Clausen, PA;Bille, RLL;Bowadt, S
通讯作者：
Bowadt, S
影响因子：
10.4
作者：
Adibi, Jennifer J;Perera, Frederica P;Jedrychowski, Wieslaw;Camann, David E;Barr, Dana;Jacek, Ryszard;Whyatt, Robin M
通讯作者：
Whyatt, Robin M
影响因子：
2.6
作者：
Beasley, R;Ellwood, P;Asher, I
通讯作者：
Asher, I
影响因子：
12.4
作者：
Bornehag, CG;Sundell, J;Janson, S
通讯作者：
Janson, S