Histone variants and modifications in plant gene regulation.
Histone variants and modifications in plant gene regulation.
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DOI：
10.1016/j.pbi.2010.11.005
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发表时间：
2011-04
影响因子：
9.5
通讯作者：
Henikoff S
中科院分区：
文献类型：
--
作者：
Deal RB;Henikoff S
基因组通过将DNA与组蛋白复合来包装，这提供了通过动态地阻碍转录调节蛋白和RNA聚合酶接近DNA来调节基因表达的机会。将组蛋白变体掺入核小体中并向组蛋白添加翻译后修饰可以改变核小体的物理性质，从而作为调节DNA暴露的机制。基于染色质的基因调控对发育过程具有深远的影响，包括营养向生殖转变的调控，以及对病原体和非生物因素的反应。组蛋白变体H2A.Z的掺入和组蛋白H3赖氨酸残基4和27的甲基化已经成为参与这些过程中的每一个的基因的调节中的关键元件。
Genomes are packaged by complexing DNA with histone proteins, which provides an opportunity to regulate gene expression by dynamically impeding access of transcriptional regulatory proteins and RNA polymerases to DNA. The incorporation of histone variants into nucleosomes and addition of post-translational modifications to histones can alter the physical properties of nucleosomes and thereby serve as a mechanism for regulating DNA exposure. Chromatin-based gene regulation has profound effects on developmental processes including regulation of the vegetative to reproductive transition, as well as responses to pathogens and abiotic factors. Incorporation of the histone variant H2A.Z and methylation of histone H3 lysine residues 4 and 27 have emerged as key elements in the regulation of genes involved in each of these processes.
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影响因子：
10.5
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通讯作者：
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