Impact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake.
Impact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake.
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DOI：
10.1016/j.ynstr.2021.100335
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发表时间：
2021-11
影响因子：
5
通讯作者：
Fanselow MS
中科院分区：
文献类型：
--
作者：
Gonzalez ST;Marty V;Spigelman I;Reise SP;Fanselow MS
经历创伤事件后可能会出现创伤后应激障碍 (PTSD)，并严重影响生活质量。创伤后应激障碍（PTSD）经常与物质使用障碍共存，其中酗酒尤其常见。然而，并不是所有经历过创伤的人都会患上创伤后应激障碍（PTSD），尽管性别似乎发挥着重要作用，但使个人对压力影响敏感或有抵抗力的因素尚不清楚。压力暴露的啮齿动物模型，例如压力增强恐惧学习（SEFL），概括了 PTSD 症状学的某些方面，使它们成为研究这种疾病的宝贵工具。这项研究检验了暴露于改良版 SEFL 程序（90 分钟内 4 次足部电击，而不是标准的 15 次足部电击）是否会同时揭示易感性和复原力受试者。承受压力后，出现了明显的易感群体和适应群体，他们在恐惧学习和焦虑相关行为以及自愿饮酒方面存在差异。与女性相比，男性压力敏感性的某些方面表现不同，男性的压力敏感性与酒精摄入量的增加有关，而女性的压力敏感性与基线焦虑的增加有关。
Post-traumatic stress disorder (PTSD) can develop after exposure to traumatic events and severely impacts the quality of life. PTSD is frequently comorbid with substance use disorders, with alcoholism being particularly common. However, not everyone who experiences trauma develops PTSD and the factors that render individuals susceptible or resilient to the effects of stress are unknown although gender appears to play an important role. Rodent models of stress exposure such as stress-enhanced fear learning (SEFL) recapitulate some aspects of PTSD symptomology, making them an invaluable tool for studying this disorder. This study examined whether exposure to a modified version of the SEFL procedure (4 footshocks instead of the standard 15 over 90 min) would reveal both susceptible and resilient subjects. Following stress exposure, distinct susceptible and resilient groups emerged that differed in fear learning and anxiety-related behavior as well as voluntary alcohol intake. Some aspects of stress susceptibility manifested differently in males compared to females, with susceptibility associated with increased alcohol intake in males and increased baseline anxiety in females.
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