In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups.
In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups.
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DOI：
10.1016/j.bioactmat.2017.02.002
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发表时间：
2017-03
影响因子：
18.9
通讯作者：
Grøndahl L
中科院分区：
文献类型：
--
作者：
Hidzir NM;Hill DJT;Martin D;Grøndahl L
合成聚合物在模拟体液（SBF）中的体外矿化仍然是一个重要的研究领域，因为结果无法预测。本研究评估了一系列接枝有含羧酸酯共聚物的ePTFE膜，特别是使用丙烯酸和衣康酸进行接枝。样品在接枝密度、羧酸盐密度和聚合物拓扑结构方面不同。在1.5 × SBF中产生的矿物的类型和数量取决于样品的XPS，SEM/EDX和FTIR光谱的特征。发现接枝密度影响形成的矿物相，并且低接枝密度似乎引起碳酸钙和磷酸钙的共沉淀。线性和支化的接枝共聚物拓扑结构导致羟基磷灰石矿化，而交联的接枝共聚物导致形成的混合物的钙-磷酸盐相。这项研究表明，在体外矿化结果含羧酸接枝共聚物是复杂的。本研究的结果对生物活性涂层的设计具有一定的意义，对于理解骨-生物材料界面具有重要意义。接枝有含羧酸酯共聚物的ePTFE膜在模拟体液中诱导矿化。接枝密度影响形成的低密度矿物相，导致碳酸钙的共沉淀。接枝共聚物的拓扑结构影响矿化结果。
In vitro mineralisation in simulated body fluid (SBF) of synthetic polymers continues to be an important area of research as the outcomes cannot be predicted. This study evaluates a series of ePTFE membranes grafted with carboxylate-containing copolymers, specifically using acrylic acid and itaconic acid for grafting. The samples differ with regards to graft density, carboxylate density and polymer topology. The type and amount of mineral produced in 1.5 × SBF was dependent on the sample characteristics as evident from XPS, SEM/EDX, and FTIR spectroscopy. It was found that the graft density affects the mineral phases that form and that low graft density appear to cause co-precipitation of calcium carbonate and calcium phosphate. Linear and branched graft copolymer topology led to hydroxyapatite mineralisation whereas crosslinked graft copolymers resulted in formation of a mixture of calcium-phosphate phases. This study demonstrates that in vitro mineralisation outcomes for carboxylate-containing graft copolymers are complex. The findings of this study have implications for the design of bioactive coatings and are important for understanding the bone-biomaterial interface. ePTFE membranes grafted with carboxylate-containing copolymers induce mineralisation in simulated body fluid. The graft density affects the mineral phases that form with low density causing co-precipitation of calcium carbonate. The topology of the graft copolymer affects the mineralization outcome.
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影响因子：
5.4
作者：
Feddes, B;Wolke, JGC;Jansen, JA
通讯作者：
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影响因子：
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作者：
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作者：
Hidzir, Norsyahidah Mohd;Hill, David J. T.;Grondahl, Lisbeth
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Grondahl, Lisbeth
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作者：
Hidzir, Norsyahidah Mohd;Hill, David J. T.;Grondahl, Lisbeth
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影响因子：
5.8
作者：
Jiang, Zhen;Yu, Yabiao;Zhang, Qiqing
通讯作者：
Zhang, Qiqing