Antibodies against G-protein coupled receptors: novel uses in screening and drug development.
Antibodies against G-protein coupled receptors: novel uses in screening and drug development.
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DOI：
10.2174/138620708784911465
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发表时间：
2008-07
影响因子：
1.8
通讯作者：
Devi LA
中科院分区：
文献类型：
--
作者：
Gupta A;Heimann AS;Gomes I;Devi LA
抗体是人体体液免疫系统的组成部分，是对外来病原体的反应。现代生物医学研究已经将这些由自然界设计的非常特异和有效的分子用于疾病的诊断、基因产物的定位以及用于药物发现和测试的靶点的快速筛选。此外，带有荧光或酶标记的抗体的引入显著促进了成像和微阵列技术的进步，这些技术正在彻底改变疾病研究和寻找有效的治疗方法。最近，抗体已用于分离二聚G蛋白偶联受体（GPCR）复合物。在这篇综述中，我们讨论了抗体作为研究GPCR的强大研究工具，以及它们本身作为药物开发的潜力。
Antibodies are components of the body’s humoral immune system that are generated in response to foreign pathogens. Modern biomedical research has employed these very specific and efficient molecules designed by nature in the diagnosis of diseases, localization of gene products as well as in the rapid screening of targets for drug discovery and testing. In addition, the introduction of antibodies with fluorescent or enzymatic tags has significantly contributed to advances in imaging and microarray technology, which are revolutionizing disease research and the search for effective therapeutics. More recently antibodies have been used in the isolation of dimeric G protein-coupled receptor (GPCR) complexes. In this review we discuss antibodies as powerful research tools for studying GPCRs, and their potential to be developed as drugs themselves.
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影响因子：
1.8
作者：
Escolar, G;Díaz-Ricartl, M;Galán, AM
通讯作者：
Galán, AM
影响因子：
3.2
作者：
HICKS, D;BARNSTABLE, CJ
通讯作者：
BARNSTABLE, CJ
影响因子：
3.3
作者：
Blanpain, C;Vanderwinden, JM;Mack, M
通讯作者：
Mack, M
影响因子：
15.9
作者：
Ando, T;Latif, R;Davies, TF
通讯作者：
Davies, TF
DOI：
10.1073/pnas.0437875100
发表时间：
2003-02-18
影响因子：
11.1
作者：
Bohen, SP;Troyanskaya, OG;Levy, R
通讯作者：
Levy, R