Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
复制标题
塑料表面的鞘氨醇涂层可预防呼吸机相关性肺炎
DOI：
10.1007/s00109-019-01800-1
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Gulbins E
中科院分区：
文献类型：
--
作者：
eitz AP;Schumacher F;Baker J;Soddemann M;Wilker B;Caldwell CC;Gobble RM;Kamler M;Becker KA;Beck S;Kleuser B;Edwards MJ;Gulbins E
呼吸机相关性肺炎（VAP）是危重病患者发病和死亡的主要原因。在这里，我们利用鞘氨醇的广泛抗菌作用，通过开发一种用鞘氨醇和鞘氨醇类似物涂覆气管内导管表面的新方法来预防VAP。气管插管的鞘氨醇和植物鞘氨醇涂层可防止粘附并介导对铜绿假单胞菌、鲍曼不动杆菌和金黄色葡萄球菌的杀灭，即使在生物膜中也是如此。最重要的是，鞘氨醇涂层的气管插管也防止P。aerodorosaandS.体内金黄色肺炎。鞘氨醇涂层的管是稳定的，没有明显的副作用气管上皮细胞和不诱导炎症。总的来说，我们描述了一种涂覆塑料表面的新方法，并为鞘氨醇和植物鞘氨醇作为新型抗菌涂层的应用提供了证据，以防止细菌粘附并诱导杀死气管内导管表面的病原体，从而防止生物膜形成和VAP。用脂类涂覆塑料表面的涂覆方法。鞘氨醇和植物鞘氨醇作为塑料表面的新型抗菌涂层。气管内导管的鞘氨醇涂层可防止细菌粘附和生物膜。气管插管鞘氨醇涂层诱导病原体的杀灭。气管插管鞘氨醇涂层与呼吸机相关性肺炎。
AbstractVentilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in critically ill patients. Here, we employed the broad antibacterial effects of sphingosine to prevent VAP by developing a novel method of coating surfaces of endotracheal tubes with sphingosine and sphingosine analogs. Sphingosine and phytosphingosine coatings of endotracheal tubes prevent adherence and mediate killing ofPseudomonas aeruginosa,Acinetobacter baumannii, andStaphylococcus aureus, even in biofilms. Most importantly, sphingosine-coating of endotracheal tubes also preventedP. aeruginosaandS. aureuspneumonia in vivo. Coating of the tubes with sphingosine was stable, without obvious side effects on tracheal epithelial cells and did not induce inflammation. In summary, we describe a novel method to coat plastic surfaces and provide evidence for the application of sphingosine and phytosphingosine as novel antimicrobial coatings to prevent bacterial adherence and induce killing of pathogens on the surface of endotracheal tubes with potential to prevent biofilm formation and VAP.Key messagesNovel dip-coating method to coat plastic surfaces with lipids.Sphingosine and phytosphingosine as novel antimicrobial coatings on plastic surface.Sphingosine coatings of endotracheal tubes prevent bacterial adherence and biofilms.Sphingosine coatings of endotracheal tubes induce killing of pathogens.Sphingosine coatings of endotracheal tubes ventilator-associated pneumonia.
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DOI：
10.1186/cc12806
发表时间：
2013-07-02
期刊：
Critical care (London, England)
影响因子：
--
作者：
Alhazzani W;Almasoud A;Jaeschke R;Lo BW;Sindi A;Altayyar S;Fox-Robichaud AE
通讯作者：
Fox-Robichaud AE
DOI：
10.1016/s1553-7250(07)33026-2
发表时间：
2007-04-01
影响因子：
2.3
作者：
Youngquist, Paul;Carroll, Michelle;Susag, Amy
通讯作者：
Susag, Amy
影响因子：
3.9
作者：
Martin, Grace E.;Boudreau, Ryan M.;Seitz, Aaron
通讯作者：
Seitz, Aaron
影响因子：
2.5
作者：
De Souza, Paula Regina;De Andrade, Denise;Watanabe, Evandro
通讯作者：
Watanabe, Evandro
影响因子：
8.8
作者：
Morris, Andrew Conway;Hay, Alasdair W.;Walsh, Timothy S.
通讯作者：
Walsh, Timothy S.