Strain differences in the distribution of N-methyl-d-aspartate and gamma (gamma)-aminobutyric acid-A receptors in rat brain.
Strain differences in the distribution of N-methyl-d-aspartate and gamma (gamma)-aminobutyric acid-A receptors in rat brain.
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大鼠脑中N-甲基-D-天冬氨酸和γ（伽马） - 氨基酸A受体的分布分布的应变差异。
DOI：
10.1016/j.lfs.2009.10.010
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发表时间：
2009-12-16
期刊：
影响因子：
6.1
通讯作者：
Tejani-Butt, Shanaz M.
中科院分区：
文献类型：
--
作者：
Lei, Yanlin;Yaroslavsky, Irene;Tejani-Butt, Shanaz M.
关键词：
Previous studies have shown that the Wistar-Kyoto (WKY) rat strain exhibits depressive symptoms such as anhedonia, psychomotor retardation, ambivalence and negative memory bias following exposure to stress. Given the involvement of excitatory glutamate and inhibitory gamma (γ)-aminobutyric acid (GABA) signaling pathways in influencing depressive behavior, the present study investigated strain differences in the distribution of central N-methyl-D-aspartate (NMDA) and GABAA receptor sites in WKY compared to their inbred counterpart, Wistar (WIS) rats. Quantitative autoradiographic analysis was used to map the binding and distribution of NMDA and GABAA receptors in various brain regions in WKY and WIS rats. Results indicated a significant difference between the two strains. Lower NMDA receptor binding was found in the anterior cingulate cortex, caudate putmen, nucleus accumbens, CA1 region of the hippocampus and the substantia nigra pars reticulata in WKY compared to WIS rats. Conversely, higher GABAA receptor binding was found in the amygdala, caudate putmen, dentate gyrus, CA2 and CA3 fields of the hippocampus, periaqueductal gray and substantia nigra pars reticulata in WKY compared to WIS rats. Given that these two rat strains differ in their behavioural, endocrine and neurochemical profile, the observed strain differences in NMDA and GABAA receptor binding suggests that these two neurotransmitter systems may be involved in the depressive and stress sensitive phenotype of the WKY rat strain.
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影响因子：
5
作者：
Bueno, CH;Zangrossi, H;Viana, MB
通讯作者：
Viana, MB
影响因子：
10.6
作者：
Auer, DP;Pütz, B;Holsboer, F
通讯作者：
Holsboer, F
影响因子：
5.3
作者：
Chhatwal, JP;Myers, KM;Davis, M
通讯作者：
Davis, M
影响因子：
--
作者：
Cotter, D;Mackay, D;Everall, I
通讯作者：
Everall, I
影响因子：
5
作者：
DENNIS, T;BEAUCHEMIN, V;LAVOIE, N
通讯作者：
LAVOIE, N