The Yin and the Yang of Transformative Research During the COVID-19 Pandemic-A Perspective.
The Yin and the Yang of Transformative Research During the COVID-19 Pandemic-A Perspective.
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COVID-19 大流行期间变革性研究的阴阳——视角。
DOI：
10.3389/fped.2021.650302
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发表时间：
2021
影响因子：
2.6
通讯作者：
Ramchandran R
中科院分区：
文献类型：
--
作者：
Sampath V;Ramchandran R
2019冠状病毒病大流行凸显了来自不同学科的科学家合作减轻本世纪人类面临的独特灾难的必要性。研究人员将指数级技术进步与科学智慧相结合的能力，在儿科研究领域取得了里程碑式的发现，并正在克服COVID-19的挑战。其中一些发现存在于一个研究领域，而不是传统的“基础”或“临床”。转化研究部分地描述了这一领域的特征，但并没有完全捕捉到激发这些发现的综合研究方法。在此，我们分享我们对基础和临床研究的共同主题的看法。我们还强调了基础研究和临床研究在范围、重点、方法和局限性方面的主要差异，这些差异阻碍了促进真正变革性研究的多学科方法。这些研究思维和方法上的差异在培训过程中根深蒂固，其中所选学科的局限性和替代学科的优势没有得到充分的探索。在精准医学时代，岛岛方法在影响复杂疾病病理生理方面尤其有限。我们建议将组学技术、系统生物学、适应性临床试验设计、人性化动物模型和精确的临床前模型系统整合到未来科学家的研究培训中。美国国立卫生研究院和其他机构的一些倡议正在促进这种基础广泛的“无边界研究”培训，为无缝、多学科的研究铺平道路。当科学挑战与一开始就愿意分享想法、解决挑战和开发工具/模型的伙伴关系一起解决时，这种努力就会成为“变革性的”。
The COVID-19 pandemic has highlighted the necessity for scientists from diverse disciplines to collaboratively mitigate the singular calamity facing humanity this century. The ability of researchers to combine exponential advances in technology and scientific acumen has resulted in landmark discoveries in pediatric research and is surmounting the COVID-19 challenge. Several of these discoveries exist in a realm of research that is not classically “basic” or “clinical.” Translational research characterizes this domain partially, but does not fully capture the integrated research approaches that have spurred these discoveries. Herein, we share our perspective on the common themes underpinning the basic and clinical research. We also highlight major differences in the scope, emphasis, approach, and limitations of basic and clinical research that impede multi-disciplinary approaches that facilitate truly transformative research. These differences in research thinking and methodology are ingrained during training wherein the limitations of the chosen discipline, and strengths of alternate disciplines are not adequately explored. Insular approaches are particularly limited in impacting complex diseases pathophysiology in the era of precision medicine. We propose that integration of -omics technologies, systems biology, adaptive clinical trial designs, humanized animal models, and precision pre-clinical model systems must be incorporated into research training of future scientists. Several initiatives from the NIH and other institutions are facilitating such broad-based “research without frontiers” training that paves the way for seamless, multi-disciplinary, research. Such efforts become “transformative” when scientific challenges are tackled in partnership with a willingness to share ideas, tackle challenges, and develop tools/models from the very beginning.
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影响因子：
5.7
作者：
Fernandez-Moure JS
通讯作者：
Fernandez-Moure JS
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Zhang F
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