RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
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DOI：
10.1038/nature13485
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发表时间：
2014-09-04
期刊：
影响因子：
64.8
通讯作者：
Wendel, Hans-Guido
中科院分区：
文献类型：
--
作者：
Wolfe, Andrew L.;Singh, Kamini;Zhong, Yi;Drewe, Philipp;Rajasekhar, Vinagolu K.;Sanghvi, Viraj R.;Mavrakis, Konstantinos J.;Jiang, Man;Roderick, Justine E.;Van der Meulen, Joni;Schatz, Jonathan H.;Rodrigo, Christina M.;Zhao, Chunying;Rondou, Pieter;de Stanchina, Elisa;Teruya-Feldstein, Julie;Kelliher, Michelle A.;Speleman, Frank;Porco, John A., Jr.;Pelletier, Jerry;Raetsch, Gunnar;Wendel, Hans-Guido
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A/DDX2 RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of Silvestrol and related compounds. For example, eIF4A promotes T-ALL development in vivo and is required for leukaemia maintenance. Accordingly, inhibition of eIF4A with Silvestrol has powerful therapeutic effects in vitro and in vivo. We use transcriptome-scale ribosome footprinting to identify the hallmarks of eIF4A-dependent transcripts. These include 5′UTR sequences such as the 12-mer guanine quartet (CGG)4 motif that can form RNA G-quadruplex structures. Notably, among the most eIF4A-dependent and Silvestrol-sensitive transcripts are a number of oncogenes, super-enhancer associated transcription factors, and epigenetic regulators. Hence, the 5′UTRs of selected cancer genes harbour a targetable requirement for the eIF4A RNA helicase.
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DOI：
10.1093/bioinformatics/btr064
发表时间：
2011-04-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Grant CE;Bailey TL;Noble WS
通讯作者：
Noble WS
影响因子：
14.9
作者：
Bugaut A;Balasubramanian S
通讯作者：
Balasubramanian S
影响因子：
48
作者：
Katz, Yarden;Wang, Eric T.;Airoldi, Edoardo M.;Burge, Christopher B.
通讯作者：
Burge, Christopher B.
影响因子：
64.5
作者：
Hnisz D;Abraham BJ;Lee TI;Lau A;Saint-André V;Sigova AA;Hoke HA;Young RA
通讯作者：
Young RA
影响因子：
4.5
作者：
Galicia-Vazquez, Gabriela;Cencic, Regina;Pelletier, Jerry
通讯作者：
Pelletier, Jerry