Self-Registration Methods for Increasing Membrane Utilization within Compression-Sealed Microchannel Hemodialysers.
Self-Registration Methods for Increasing Membrane Utilization within Compression-Sealed Microchannel Hemodialysers.
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DOI：
10.1016/j.jmapro.2014.08.001
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发表时间：
2014-10
影响因子：
6.2
通讯作者：
Porter, Spencer D.
中科院分区：
文献类型：
--
作者：
Paul, Brian K.;Porter, Spencer D.
全世界有超过120万人需要定期血液透析治疗终末期肾衰竭。目前的血液透析系统过于昂贵，无法支持家庭血液透析，更频繁和更长时间的治疗可以导致更好的患者结果。血液透析器的主要成本驱动因素是血液透析膜的成本。微通道血液透析器更小，可以使用更少的膜。先前的工作已经证明了使用密封凸台在微通道血液透析器中形成压缩密封。在本文中，估计表明，用于传质的膜的百分比高度依赖于相邻血液和透析液薄层的设计和配准精度。这里的努力集中在开发一种自配准方法，以使聚碳酸酯层与用于膜分离应用的压缩密封方案相容。自嵌套配准方法得到证实，在50 mm尺度上测量的平均配准精度为11.4 ± 7.2 μm。分析表明，在压印过程中，套准精度受到公差的制约。使用自嵌套配准方法生产透析供试品，显示测得的平均一维配准误差为18.5 μm，当考虑微通道和顶盖区域时，允许41.4%的膜用于传质。传质结果提供了证据，在现有文献中的其他设计的膜利用率的两倍至三倍的增加。
More than 1.2 million people worldwide require regular hemodialysis therapy to treat end stage renal failure. Current hemodialysis systems are too expensive to support at-home hemodialysis where more frequent and longer duration treatment can lead to better patient outcomes. The key cost driver for hemodialysers is the cost of the hemodialysis membrane. Microchannel hemodialysers are smaller providing the potential to use significantly less membrane. Prior work has demonstrated the use of sealing bosses to form compression seals in microchannel hemodialysers. In this paper, estimates show that the percentage of the membrane utilized for mass transfer is highly dependent on the design and registration accuracy of adjacent blood and dialysate laminae. Efforts here focus on the development of a self-registration method to align polycarbonate laminae compatible with compression sealing schemes for membrane separation applications. Self-nesting registration methods were demonstrated with average registration accuracies of 11.4 ± 7.2 μm measured over a 50 mm scale. Analysis shows that the registration accuracy is constrained by tolerances in the embossing process. A dialysis test article was produced using the self-nesting registration method showing a measured average one-dimensional misregistration of 18.5 μm allowing a potential 41.4% of the membrane to be utilized for mass transfer when considering both microchannel and header regions. Mass transfer results provide evidence of a twofold to threefold increase in membrane utilization over other designs in the existing literature.
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影响因子：
3
作者：
Vanholder, Raymond;Van Laecke, Steven;Glorieux, Griet
通讯作者：
Glorieux, Griet
DOI：
10.1115/1.1811112
发表时间：
2004-11-01
影响因子：
4
作者：
Wattanutchariya, W;Paul, BK
通讯作者：
Paul, BK
DOI：
10.1016/s0272-6386(03)00534-1
发表时间：
2003-07-01
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Lindsay, Robert M;Alhejaili, Fayez;Kortas, Claude
通讯作者：
Kortas, Claude
DOI：
10.1016/s1073-4449(99)70048-8
发表时间：
1999-10-01
期刊：
ADVANCES IN RENAL REPLACEMENT THERAPY
影响因子：
--
作者：
McPhatter, LL;Lockridge, RS;Coffey, L
通讯作者：
Coffey, L
影响因子：
6.1
作者：
Kang, Joo H.;Kim, Yu Chang;Park, Je-Kyun
通讯作者：
Park, Je-Kyun