Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications.
Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications.
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DOI：
10.1007/s10555-016-9633-1
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发表时间：
2016-09
影响因子：
9.2
通讯作者：
De Rossi, Anita
中科院分区：
文献类型：
--
作者：
Boscolo-Rizzo, Paolo;Da Mosto, Maria Cristina;Rampazzo, Enrica;Giunco, Silvia;Del Mistro, Annarosa;Menegaldo, Anna;Baboci, Lorena;Mantovani, Monica;Tirelli, Giancarlo;De Rossi, Anita
关键词：
头颈部鳞状细胞癌（HNSCC）与吸烟、酗酒和高危人乳头瘤病毒（HPV）感染密切相关，是一种常见的致死性异质性疾病，其发病机制是一个涉及遗传和表观遗传事件的多步骤和多因素过程。大多数HNSCC患者表现为局部晚期疾病，并采用联合治疗策略进行治疗，这些策略可显著损害生活质量并引起不可预测的结果。大部分接受局部治疗并获得完全缓解的患者后来发生局部复发或第二区域肿瘤。因此，能够对风险进行分层并使临床医生能够定制治疗计划和个性化治疗后监测策略的生物标志物是非常可取的。迄今为止，只有HPV状态被认为是口咽部位HNSCC患者治疗反应和生存的可靠独立预测因素。最近的研究表明，端粒磨损（可能是人类致癌的早期事件）和端粒酶激活（在高达90%的恶性肿瘤中检测到）可能是癌症风险和疾病结局的潜在标志物。本文就端粒功能障碍和端粒酶激活在HNSCC发生发展和临床转归中的作用进行综述。
Strongly associated with tobacco use, heavy alcohol consumption, and with high-risk human papillomavirus (HPV) infection, head and neck squamous cell carcinoma (HNSCC) is a frequently lethal, heterogeneous disease whose pathogenesis is a multistep and multifactorial process involving genetic and epigenetic events. The majority of HNSCC patients present with locoregional advanced stage disease and are treated with combined modality strategies that can markedly impair quality of life and elicit unpredictable results. A large fraction of those who undergo locoregional treatment and achieve a complete response later develop locoregional recurrences or second field tumors. Biomarkers that are thus able to stratify risk and enable clinicians to tailor treatment plans and to personalize post-therapeutic surveillance strategies are highly desirable. To date, only HPV status is considered a reliable independent predictor of treatment response and survival in patients with HNSCC arising from the oropharyngeal site. Recent studies suggest that telomere attrition, which may be an early event in human carcinogenesis, and telomerase activation, which is detected in up to 90 % of malignancies, could be potential markers of cancer risk and disease outcome. This review examines the current state of knowledge on and discusses the implications linked to telomere dysfunction and telomerase activation in the development and clinical outcome of HNSCC.
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影响因子：
7.8
作者：
Bazarov AV;Van Sluis M;Hines WC;Bassett E;Beliveau A;Campeau E;Mukhopadhyay R;Lee WJ;Melodyev S;Zaslavsky Y;Lee L;Rodier F;Chicas A;Lowe SW;Benhattar J;Ren B;Campisi J;Yaswen P
通讯作者：
Yaswen P
影响因子：
8.8
作者：
Bertorelle, R.;Briarava, M.;Rampazzo, E.;Biasini, L.;Agostini, M.;Maretto, I.;Lonardi, S.;Friso, M. L.;Mescoli, C.;Zagonel, V.;Nitti, D.;De Rossi, A.;Pucciarelli, S.
通讯作者：
Pucciarelli, S.
DOI：
10.1073/pnas.112515399
发表时间：
2002-06-11
影响因子：
11.1
作者：
Artandi, SE;Alson, S;DePinho, RA
通讯作者：
DePinho, RA
影响因子：
4.8
作者：
Boscolo-Rizzo, Paolo;Rampazzo, Enrica;De Rossi, Anita
通讯作者：
De Rossi, Anita
DOI：
10.1056/nejmoa0912217
发表时间：
2010-07-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ang KK;Harris J;Wheeler R;Weber R;Rosenthal DI;Nguyen-Tân PF;Westra WH;Chung CH;Jordan RC;Lu C;Kim H;Axelrod R;Silverman CC;Redmond KP;Gillison ML
通讯作者：
Gillison ML