Induction of apoptosis and cell cycle arrest in human colorectal carcinoma by Litchi seed extract.
Induction of apoptosis and cell cycle arrest in human colorectal carcinoma by Litchi seed extract.
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DOI：
10.1155/2012/341479
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发表时间：
2012
影响因子：
--
通讯作者：
Chung YC
中科院分区：
文献类型：
--
作者：
Hsu CP;Lin CC;Huang CC;Lin YH;Chou JC;Tsia YT;Su JR;Chung YC
荔枝（Litchi chinensis）果实产品含有丰富的类黄酮和原花青素。它的果皮已被证明能抑制乳腺癌和肝癌细胞的生长。然而，荔枝籽提取物的抗结直肠癌作用尚未见报道。本实验研究了富多酚荔枝籽乙醇提取物（LCSP）对结肠直肠癌细胞系Colo320DM和SW480增殖、细胞周期和凋亡的影响。结果表明，LCSP显著诱导结直肠癌细胞凋亡，并呈剂量依赖性，阻滞G2/M细胞周期。LCSP还能抑制细胞周期蛋白，提高Bax: Bcl-2比值和caspase 3活性。本研究提供了LCSP作为一种潜在的结直肠癌化学预防剂的体外证据。
The Litchi (Litchi chinensis) fruit products possess rich amounts of flavanoids and proanthocyanidins. Its pericarp has been shown to inhibit breast and liver cancer cell growth. However, the anticolorectal cancer effect of Litchi seed extract has not yet been reported. In this study, the effects of polyphenol-rich Litchi seed ethanol extract (LCSP) on the proliferation, cell cycle, and apoptosis of two colorectal cancer cell lines Colo320DM and SW480 were examined. The results demonstrated that LCSP significantly induced apoptotic cell death in a dose-dependent manner and arrested cell cycle in G2/M in colorectal carcinoma cells. LCSP also suppressed cyclins and elevated the Bax : Bcl-2 ratio and caspase 3 activity. This study provides in vitro evidence that LCSP serves as a potential chemopreventive agent for colorectal cancer.
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影响因子：
4.7
作者：
Mantena, Sudheer K.;Baliga, Manjeshwar S.;Katiyar, Santosh K.
通讯作者：
Katiyar, Santosh K.
影响因子：
6
作者：
Ariga, T
通讯作者：
Ariga, T
影响因子：
64.8
作者：
Reed, JC
通讯作者：
Reed, JC
细胞周期蛋白D1降解的调节：在癌症发展中的作用和治疗发明的潜力。
影响因子：
37.3
作者：
Alao, John P.
通讯作者：
Alao, John P.
影响因子：
2.9
作者：
Chung, Yuan-Chiang;Huang, Chiu-Chen;Hsu, Chih-Ping
通讯作者：
Hsu, Chih-Ping