Effect of prenatal dog exposure on eczema development in early and late childhood.
Effect of prenatal dog exposure on eczema development in early and late childhood.
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DOI：
10.1016/j.jaip.2022.09.007
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发表时间：
2022-12
影响因子：
9.4
通讯作者：
Zoratti, Edward
中科院分区：
文献类型：
--
作者：
Eapen, Amy A.;Sitarik, Alexandra R.;Cheema, Gagandeep;Kim, Haejin;Ownby, Dennis;Johnson, Christine C.;Zoratti, Edward
儿童早期的兴奋，通常是“特应性进行曲”的开始，增加了随后发生特应性疾病（食物过敏，过敏性哮喘和过敏性鼻炎）的可能性1，2。可改变的环境危险因素，重要的湿疹发病机制，可能是潜在的干预措施。研究表明，国内宠物湿疹发展的保护作用3，4。以前的报告集中在湿疹在幼儿期，但没有解决在儿童后期的潜在影响3，4。本研究比较了韦恩县健康、环境、过敏和哮喘纵向研究（WHEALS）中出生前和第一年狗在幼儿期（2岁）和幼儿期（10岁）暴露于湿疹的相关性，WHEALS是一项种族和社会经济多样化的出生队列研究。我们还评估了产前犬暴露是否与2 - 10岁湿疹的持续或消退相关，以及犬是否与特应性和非特应性湿疹相关。WHEALS招募了2003年9月至2007年12月居住在底特律大都会地区的孕妇（21-49岁）。参与者提供知情同意书，研究方案由亨利福特健康（HFH）机构审查委员会批准5。我们的分析包括在2岁和/或10岁时完成产前访谈并在研究诊所访视期间由医生评估湿疹病史的母婴对（N= 794;图E1）。通过患者病史和体检，医生评估了每个孩子随着时间的推移的湿疹病史。“仅早期湿疹”是指在2岁之前或在2岁时诊断出湿疹，但在10岁时没有湿疹。“仅晚期湿疹”是指10岁但不≤ 2岁时的湿疹诊断。“持续性湿疹”是指湿疹诊断年龄
Eczema in early childhood, often the start of the “atopic march”, increases the likelihood of developing subsequent atopic conditions (food allergy, allergic asthma, and allergic rhinitis) 1, 2. Modifiable environmental risk factors, important to eczema pathogenesis, may represent potential interventions. Studies demonstrate protective effects of domestic pets on eczema development3, 4. Previous reports focus on eczema in early childhood but do not address potential effects in late childhood3, 4. This study compares the associations of prenatal and first-year dog exposure to eczema in early childhood (age 2 years) and late childhood (age 10 years) in the Wayne County Health, Environment, Allergy and Asthma Longitudinal study (WHEALS), a racially and socioeconomically diverse birth cohort. We also assessed whether prenatal dog exposure is associated with persistence or resolution of eczema from age 2 to 10 years and whether dogs are associated with atopic and non-atopic eczema.WHEALS enrolled pregnant women (21–49 years) due September 2003-December 2007 residing in the metro-Detroit area. Participants provided informed consent, and study protocols were approved by the Henry Ford Health (HFH) Institutional Review Board5. Our analysis included maternal-child pairs who completed a prenatal interview and had eczema history evaluated by a physician during study clinic visits at age 2 and/or 10 years (N= 794; Figure E1). Using patient history and physical examination, physicians assessed each child’s history of eczema over time.“Early eczema only” refers to eczema diagnosis prior to or at age 2, but no eczema at age 10.“Late eczema only” refers to current eczema diagnosis at age 10, but not≤ 2 years.“Persistent eczema” refers to eczema diagnosis at age
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DOI：
10.1111/j.1365-2222.2011.03946.x
发表时间：
2012-06
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Wegienka G;Havstad S;Joseph CL;Zoratti E;Ownby D;Woodcroft K;Johnson CC
通讯作者：
Johnson CC
影响因子：
14.2
作者：
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通讯作者：
Chatenoud, Liliane
DOI：
10.1016/j.anai.2017.10.037
发表时间：
2018-03
期刊：
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
影响因子：
--
作者：
Hill DA;Spergel JM
通讯作者：
Spergel JM
影响因子：
4.4
作者：
Kurukulaaratchy, R;Fenn, M;Arshad, SH
通讯作者：
Arshad, SH
影响因子：
12.4
作者：
Thorsteinsdottir, S.;Thyssen, J. P.;Bisgaard, H.
通讯作者：
Bisgaard, H.