Association of C7673T polymorphism in apolipoprotein B gene with ischemic stroke in the Chinese population: a meta-analysis
Association of C7673T polymorphism in apolipoprotein B gene with ischemic stroke in the Chinese population: a meta-analysis
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载脂蛋白B基因C7673T多态性与中国人群缺血性脑卒中相关性的荟萃分析
DOI：
10.3109/00207454.2015.1052429
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发表时间：
2015-05
影响因子：
2.2
通讯作者：
Ma, Minmin
中科院分区：
文献类型：
--
作者：
Ni, Guihua;Qian, Yun;Han, Yunfei;Ma, Minmin
背景：流行病学研究已经评估了载脂蛋白B （apoB）基因C7673T多态性与缺血性卒中（IS）之间的关系，但即使在中国人群中，结果仍然存在争议。因此，本荟萃分析旨在澄清这些争议。方法：截至2014年10月31日，所有相关研究均从PubMed、Embase、中国国家知识基础数据库和中国万方数据库中检索。采用Revman 5.2和STATA 12.0软件进行统计学分析。应用比值比（OR）和95%置信区间（CI）值来评估这种关联的强度。在异质性检验的基础上，选择固定效应或随机效应模型进行数据池化。采用Begg检验和Egger检验评估发表偏倚。结果：载脂蛋白ob基因C7673T多态性与IS在杂合子遗传模型（OR = 1.868, 95% CI = 1.160 ~ 3.007）和等位基因遗传模型（OR = 1.742, 95% CI = 1.294 ~ 2.346）下存在显著相关性。在地理区域亚组分析中，T等位基因可增加中国北方人患IS的风险（OR = 2.359, 95% CI: 1.425-3.907），但在中国南方个体中没有（OR = 1.485, 95% CI: 0.778-2.832）。进一步的对照来源分层显示，在以人群为基础的研究中发现了统计学意义。结论：我们的荟萃分析显示，载脂蛋白b基因C7673T多态性与中国人群IS风险增加显著相关。
Background: Epidemiological studies have evaluated the association between the C7673T polymorphism in apolipoprotein B (apoB) gene and ischemic stroke (IS), but the results are still debatable even in the Chinese population. This meta-analysis was therefore designed to clarify these controversies. Methods: All of the relevant studies were identified from PubMed, Embase, Chinese National Knowledge Infrastructure database and Chinese Wanfang database up to 31 October 2014. Statistical analyses were conducted with Revman 5.2 and STATA 12.0 software. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association. A fixed or random effect model was selected for pooling data based on the heterogeneity test. Publication bias was assessed by Begg's test and Egger's test. Results: A significant association was found between the C7673T polymorphism in apoB gene and IS under the heterozygous genetic model (OR = 1.868, 95% CI = 1.160–3.007) and the allelic genetic model (OR = 1.742, 95% CI = 1.294–2.346), respectively. In the subgroup analysis by the geographic region, T allele could increase the risk of IS in northern Chinese (OR = 2.359, 95% CI: 1.425–3.907), but not in southern Chinese individuals (OR = 1.485, 95% CI: 0.778–2.832). Further stratification for source of controls showed that statistical significance was found among the population-based studies. Conclusion: Our meta-analysis revealed that C7673T polymorphism in apoB gene was significantly associated with increased IS risk in the Chinese population.
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影响因子：
--
作者：
L. Wang;Y. Gu;G. Wu
通讯作者：
L. Wang;Y. Gu;G. Wu
DOI：
10.1016/0021-9681(79)90031-6
发表时间：
1979
期刊：
Journal of Chronic Diseases
影响因子：
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作者：
R. Horwitz
通讯作者：
R. Horwitz
DOI：
10.1016/s0734-3299(08)70393-9
发表时间：
2007
期刊：
Yearbook of Critical Care Medicine
影响因子：
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作者：
J. Provencio
通讯作者：
J. Provencio
影响因子：
2.7
作者：
Le Zhang;Yi Zeng;Ming-ming Ma;Qi-dong Yang;Zhong-yang Hu;Xiao-ping Du
通讯作者：
Le Zhang;Yi Zeng;Ming-ming Ma;Qi-dong Yang;Zhong-yang Hu;Xiao-ping Du
DOI：
10.1016/0005-2760(93)90136-w
发表时间：
1993-01
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Alison M. Dunning;H. Renges;A. Hamsten;P. Talmud;S. Humphries
通讯作者：
Alison M. Dunning;H. Renges;A. Hamsten;P. Talmud;S. Humphries