Serum albumin concentration and cognitive impairment.
Serum albumin concentration and cognitive impairment.
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DOI：
10.2174/156720510790274392
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发表时间：
2010-02
影响因子：
2.1
通讯作者：
Lang IA
中科院分区：
文献类型：
--
作者：
Llewellyn DJ;Langa KM;Friedland RP;Lang IA
临床样本的结果表明低血清白蛋白可能与认知障碍有关，尽管基于人群的研究证据尚无定论。参与者是 2000 年英格兰健康调查（一项具有全国代表性的基于人口的研究）中 1,752 名年龄在 65 岁及以上的成年人（699 名男性和 1,053 名女性）。使用简略心理测试分数评估认知障碍。使用逻辑回归对血清白蛋白四分位数与认知障碍的横截面关系进行建模。 212 名参与者患有认知障碍（68 名男性和 144 名女性）。血清白蛋白第一四分位数（2.2–3.8 g/dl）、第二四分位数（3.9–4.0 g/dl）和第三四分位数（4.1–4.3 g/dl）与第四四分位数（4.4–5.3 g/dl）相比，认知障碍的比值比（95%置信区间）分别为2.5（1.3–5.1）、1.7（0.9–3.5）和调整年龄、性别、教育程度和认知障碍的其他危险因素后，为 1.5 (0.7–2.9)（线性趋势 p = 0.002）。在男性和女性中观察到了高度相似的关联模式。我们的数据提供了新的证据，表明低血清白蛋白与老年人群认知障碍几率增加独立相关。
Results from clinical samples suggest low serum albumin may be associated with cognitive impairment, though evidence from population-based studies is inconclusive. Participants were 1,752 adults (699 men and 1,053 women) aged 65 years and over from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed using the Abbreviated Mental Test Score. The cross-sectional relation of serum albumin quartiles to cognitive impairment was modelled using logistic regression. Two hundred and twelve participants were cognitively impaired (68 men and 144 women). Odds ratios (95% confidence intervals) for cognitive impairment in the first (2.2–3.8 g/dl), second (3.9–4.0 g/dl), and third (4.1–4.3 g/dl) quartiles of serum albumin compared with the fourth (4.4–5.3 g/dl) were 2.5 (1.3–5.1), 1.7 (0.9–3.5), and 1.5 (0.7–2.9), after adjustment for age, sex, education and additional risk factors for cognitive impairment (p for linear trend = 0.002). A highly similar pattern of associations was observed for men and women. Our data provide new evidence to suggest that low serum albumin is independently associated with increased odds of cognitive impairment in the elderly population.
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影响因子：
3.9
作者：
SORIANI, M;PIETRAFORTE, D;MINETTI, M
通讯作者：
MINETTI, M
影响因子：
5
作者：
DOUMAS, BT;WATSON, WA;BIGGS, HG
通讯作者：
BIGGS, HG
影响因子：
6.7
作者：
HODKINSON H M
通讯作者：
HODKINSON H M
影响因子：
15
作者：
Milojevic, Julijana;Esposito, Veronica;Melacini, Giuseppe
通讯作者：
Melacini, Giuseppe
影响因子：
3.5
作者：
Peila, R.;Launer, L. J.
通讯作者：
Launer, L. J.