Effects of repeated risperidone exposure on serotonin receptor subtypes in developing rats.
Effects of repeated risperidone exposure on serotonin receptor subtypes in developing rats.
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DOI：
10.1016/j.euroneuro.2009.09.002
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发表时间：
2010-03
影响因子：
5.6
通讯作者：
Tarazi, Frank I.
中科院分区：
文献类型：
--
作者：
Choi, Yong Kee;Moran-Gates, Taylor;Gardner, Matthew P.;Tarazi, Frank I.
关键词：
利培酮是一种非典型的抗精神病药物，广泛用于患有不同精神障碍的年轻患者。这种抗精神病药物对发育中大脑神经元受体的长期影响尚不清楚，需要进一步研究。在这项研究中，我们研究了长期治疗利培酮对幼年大鼠脑区两种5-羟色胺受体亚型的影响。用三种不同剂量的利培酮（0.3、1.0和3.0 mg/kg）治疗3周后，定量幼年大鼠前脑区域中5-HT 1A和5-HT 2A受体的水平。将结果与先前报道的成年大鼠脑中利培酮治疗（3.0 mg/kg）后5-HT受体的变化进行比较。三种剂量的利培酮选择性地和剂量依赖性地增加幼年动物内侧前额叶和背外侧额叶皮质中5-HT 1A受体的水平。高剂量（1.0和3.0 mg/kg）利培酮也增加幼年大鼠海马CA 1区5-HT 1A受体结合，但成年大鼠无此作用。与此相反，三种剂量的利培酮显着减少5-HT 2A标记的内侧前额叶和背外侧额叶皮质在青少年以及成年动物在一个等效的方式。重复利培酮治疗未改变前脑其他区域的5-HT 1A和5-HT 2A受体。这些发现表明，有不同的影响利培酮对5-HT 1A和5-HT 2A受体在幼年动物，5-HT系统在发育中的动物比成年人更敏感利培酮的长期影响。
Risperidone is an atypical antipsychotic drug that is widely prescribed to young patients with different psychotic disorders. The long-term effects of this antipsychotic agent on neuronal receptors in developing brain remain unclear and require further investigation. In this study, we examined the effects of long-term treatment of risperidone on two serotonin receptor subtypes in brain regions of juvenile rat. Levels of 5-HT1A and 5-HT2A receptors in forebrain regions of juvenile rats were quantified after 3 weeks of treatment with three different doses of risperidone (0.3, 1.0 and 3.0 mg/kg). Findings were compared to previously reported changes in 5-HT receptors after risperidone treatment (3.0 mg/kg) in adult rat brain. The three doses of risperidone selectively and dose-dependently increased levels of 5-HT1A receptors in medial prefrontal and dorsolateral frontal cortices of juvenile animals. The higher doses (1.0 and 3.0 mg/kg) of risperidone also increased 5-HT1A receptor binding in hippocampal CA1 region of juvenile but not adult rats. In contrast, the three doses of risperidone significantly reduced 5-HT2A labeling in medial prefrontal and dorsolateral frontal cortices in juvenile as well as in adult animals in an equipotent fashion. 5-HT1A and 5-HT2A receptors in other forebrain regions were not altered by repeated risperidone treatment. These findings indicate that there are differential effects of risperidone on 5-HT1A and 5-HT2A receptors in juvenile animals, and that the 5-HT system in developing animals is more sensitive than adults to the long-term effects of risperidone.
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影响因子：
4.3
作者：
Erickson, Craig A;Stigler, Kimberly A;McDougle, Christopher J
通讯作者：
McDougle, Christopher J
影响因子：
1.9
作者：
Grcevich, SJ;Findling, RL;Schulz, SC
通讯作者：
Schulz, SC
DOI：
10.1097/00004583-199209000-00027
发表时间：
1992-09-01
影响因子：
13.3
作者：
GREEN, WH;PADRONGAYOL, M;BASSIRI, M
通讯作者：
BASSIRI, M
DOI：
10.1016/0736-5748(87)90027-x
发表时间：
1987-01-01
影响因子：
1.8
作者：
DAVAL, G;VERGE, D;HAMON, M
通讯作者：
HAMON, M
DOI：
10.1097/00004583-199510000-00012
发表时间：
1995-10-01
影响因子：
13.3
作者：
ALAGHBANDRAD, J;MCKENNA, K;RAPOPORT, JL
通讯作者：
RAPOPORT, JL