Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury.

Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury.
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细胞外囊泡:肺部炎症与损伤中细胞间相互作用的新兴介质

DOI:
10.3389/fimmu.2018.00924
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发表时间:
2018
影响因子:
7.3
通讯作者:
Jin Y
Jin Y
中科院分区:
医学2区
文献类型:
--
作者:
Lee H;Abston E;Zhang D;Rai A;Jin Y

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炎症性肺反应是许多肺部疾病发病机制的特征之一,包括急性呼吸窘迫综合征(ARDS)和慢性阻塞性肺疾病(COPD)。肺泡巨噬细胞和肺泡上皮细胞是宿主防御和天然免疫的第一道防线。由于它们在炎症性肺反应的起始和消退中的中心作用,AM不断地与其他肺细胞(包括肺泡上皮细胞)通信。在过去,新出现的证据表明,细胞外囊泡在细胞间串扰中起着至关重要的作用。本文就EV介导的肺上皮细胞与肺泡巨噬细胞间信号传递的研究进展作一综述。
Inflammatory lung responses are one of the characterized features in the pathogenesis of many lung diseases, including acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). Alveolar macrophages (AMs) and alveolar epithelial cells are the first line of host defense and innate immunity. Due to their central roles in both the initiation and resolution of inflammatory lung responses, AMs constantly communicate with other lung cells, including the alveolar epithelial cells. In the past, emerging evidence suggests that extracellular vesicles play an essential role in cell–cell crosstalk. In this review, we will discuss the recent findings on the intercellular communications between lung epithelial cells and alveolar macrophages, via EV-mediated signal transfer.
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