Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less.
Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less.
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DOI：
10.1186/1471-2407-10-557
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发表时间：
2010-10-15
期刊：
影响因子：
3.8
通讯作者：
Ha SW
中科院分区：
文献类型：
--
作者：
Kwon JH;Kim YJ;Lee KW;Oh DY;Park SY;Kim JH;Chie EK;Kim SW;Im SA;Kim IA;Kim TY;Park IA;Noh DY;Bang YJ;Ha SW
对于肿瘤大小≤1 cm（包括T1 mic）的淋巴结阴性早期乳腺癌患者，是否需要全身性辅助治疗是一个有争议的领域。我们对2000年1月至2006年12月间接受手术治疗的所有淋巴结阴性T1 mic、T1 a和T1 b浸润性导管癌患者的临床和病理学资料进行了回顾性分析。确定无复发生存期（RFS）和复发的危险因素。在3889例诊断为乳腺癌的患者中，375例患者入组（T1 mic：120例，T1 a：93例，T1 b：162例）。诊断时的平均年龄为49岁。中位随访60.8个月后，12例患者复发（T1 mic：4（3.3%），T1 a：2（2.2%），T1 b：6（3.7%）），5年累积RFS率为97.2%。在3例患者中发现了远处复发。年龄小于35岁（HR 4.91; 95% CI 1.014-23.763，p = 0.048）和三阴性疾病（HR 4.93; 95% CI 1.312-18.519，p = 0.018）与较高的复发率显著相关。HER 2过表达、Ki-67和p53状态不影响RFS。T1 mic、T1 a和T1 b淋巴结阴性乳腺癌的预后极好，但35岁以下或三阴性疾病的患者复发风险相对较高。
Whether a systemic adjuvant treatment is needed is an area of controversy in patients with node-negative early breast cancer with tumor size of ≤1 cm, including T1mic. We performed a retrospective analysis of clinical and pathology data of all consecutive patients with node-negative T1mic, T1a, and T1b invasive ductal carcinoma who received surgery between Jan 2000 and Dec 2006. The recurrence free survival (RFS) and risk factors for recurrence were identified. Out of 3889 patients diagnosed with breast cancer, 375 patients were enrolled (T1mic:120, T1a:93, T1b:162). Median age at diagnosis was 49. After a median follow up of 60.8 months, 12 patients developed recurrences (T1mic:4 (3.3%), T1a:2 (2.2%), T1b:6 (3.7%)), with a five-year cumulative RFS rate of 97.2%. Distant recurrence was identified in three patients. Age younger than 35 years (HR 4.91; 95% CI 1.014-23.763, p = 0.048) and triple negative disease (HR 4.93; 95% CI 1.312-18.519, p = 0.018) were significantly associated with a higher rate of recurrence. HER2 overexpression, Ki-67, and p53 status did not affect RFS. Prognosis of node-negative breast cancer with T1mic, T1a and T1b is excellent, but patients under 35 years of age or with triple negative disease have a relatively high risk of recurrence.
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影响因子：
3.8
作者：
Soerjomataram, Isabelle;Louwman, Marieke W. J.;Ribot, Jacques G.;Roukema, Jan A.;Coebergh, Jan Willem W.
通讯作者：
Coebergh, Jan Willem W.
影响因子：
6.4
作者：
Louwman, WJ;van Beek, MWPM;Coebergh, JWW
通讯作者：
Coebergh, JWW
影响因子：
45.3
作者：
Hugh, Judith;Hanson, John;Vogel, Charles
通讯作者：
Vogel, Charles
影响因子：
3.7
作者：
Jung, So-Youn;Han, Wonshik;Noh, Dong-Young
通讯作者：
Noh, Dong-Young
影响因子：
45.3
作者：
Chia, SK;Speers, CH;Olivotto, IA
通讯作者：
Olivotto, IA