Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060).

Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060).
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DOI:
10.1002/alz.12362
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发表时间:
2021-12
影响因子:
14
通讯作者:
Evans, Denis A.
Evans, Denis A.
中科院分区:
医学1区
文献类型:
--
作者:
Rajan, Kumar B.;Weuve, Jennifer;Barnes, Lisa L.;McAninch, Elizabeth A.;Wilson, Robert S.;Evans, Denis A.

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对临床AD和MCI患者的估计提供了对疾病负担的理解。我们使用拟二项回归模型对10,342名具有认知测试分数的参与者进行了估计。2020年美国人口普查调整的临床AD患病率为11.3%(95%CI = 10.7,11.9):非西班牙裔白人为10.0%,西班牙裔为14.0%,非西班牙裔非洲裔美国人为18.6%。我们估计,到2020年,607万(95%CI = 5.75,6.38)人患有临床AD,到2060年增加到1385万(95%CI = 12.98,14.74)人,西班牙裔人高出423%,非洲裔美国人高出192%,白人高出63%。然而,与男子相比,85岁以上和妇女在晚年的增长更为显著。随着“婴儿潮”一代进入老年,临床AD患者的数量将增加,对疾病负担产生强烈的向上影响。
The estimate of people with clinical AD and MCI provides an understanding of the disease burden. We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores. The 2020 US census adjusted prevalence of clinical AD was 11.3% (95% CI= 10.7, 11.9): 10.0% among non-Hispanic Whites, 14.0% among Hispanics, and 18.6% among non-Hispanic African Americans. We estimate that in 2020, 6.07 (95% CI= 5.75, 6.38) million people live with clinical AD that increases to 13.85 (95% CI= 12.98, 14.74) million in 2060, a 423% higher among Hispanics and 192% higher among African Americans, and 63% higher among Whites. However, more significant increases in later years among over 85 and women compared to men. The number of people with clinical AD will increase as the “baby boom” generation reaches older ages exerting a strong upward influence on disease burden.
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