Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response.
Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response.
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DOI：
10.1007/s12640-018-9962-7
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发表时间：
2019-08
影响因子：
3.7
通讯作者：
Kingsbury MA
中科院分区：
文献类型：
--
作者：
Bordt EA;Smith CJ;Demarest TG;Bilbo SD;Kingsbury MA
神经内分泌和免疫信号通路在应激、损伤和感染等损伤后被激活，以恢复体内平衡的全身反应。线粒体代谢和功能与免疫反应的控制有关。通常沿着线粒体功能的研究，活性氧（ROS）与细胞炎症反应密切相关。还接受的是，经历线粒体或内质网（ER）应激的细胞诱导应答途径，以在称为未折叠蛋白应答（UPR）的稳态应答中科普蛋白质折叠失调。最近的报道表明，UPR可能在免疫应答中发挥重要作用。值得注意的是，稳态调节激素催产素（OXT）和加压素（AVP）也与炎症反应和免疫功能的调节有关。有趣的是，OXT和AVP与ER未折叠蛋白反应（UPRER）有关，并且可以影响ROS产生和线粒体功能。在这里，我们将审查这些不同的因素之间的相互作用的证据，以及这些神经肽可能会影响线粒体过程。
Neuroendocrine and immune signaling pathways are activated following insults such as stress, injury, and infection, in a systemic response aimed at restoring homeostasis. Mitochondrial metabolism and function have been implicated in the control of immune responses. Commonly studied along with mitochondrial function, reactive oxygen species (ROS) are closely linked to cellular inflammatory responses. It is also accepted that cells experiencing mitochondrial or endoplasmic reticulum (ER) stress induce response pathways in order to cope with protein folding dysregulation, in homeostatic responses referred to as the unfolded protein responses (UPRs). Recent reports indicate that the UPRs may play an important role in immune responses. Notably, the homeostasis-regulating hormones oxytocin (OXT) and vasopressin (AVP) are also associated with the regulation of inflammatory responses and immune function. Intriguingly, OXT and AVP have been linked with ER unfolded protein responses (UPRER), and can impact ROS production and mitochondrial function. Here, we will review the evidence for interactions between these various factors and how these neuropeptides might influence mitochondrial processes.
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