Prognostic impact of EMT (epithelial-mesenchymal-transition)-related protein expression in endometrial cancer.
Prognostic impact of EMT (epithelial-mesenchymal-transition)-related protein expression in endometrial cancer.
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DOI：
10.4161/cbt.22625
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发表时间：
2013-01
影响因子：
3.6
通讯作者：
Ohmichi M
中科院分区：
文献类型：
--
作者：
Tanaka Y;Terai Y;Kawaguchi H;Fujiwara S;Yoo S;Tsunetoh S;Takai M;Kanemura M;Tanabe A;Ohmichi M
目的：上皮-间充质-转化(EMT)是肿瘤侵袭转移的重要环节。这一过程的一个关键分子特征是E-钙粘蛋白表达下调，主要由Snail相关的锌指转录因子(Snail和Slug)控制。本研究的目的是评估EMT相关蛋白(E-钙粘蛋白、Snail和Slug)在子宫内膜癌中的表达对预后的影响。方法：采用免疫组织化学方法，对354例子宫内膜癌原发灶和30例子宫内膜癌转移灶标本进行免疫组织化学分析，探讨其与临床病理特征及预后的关系。结果：在39.8%的原发肿瘤中，E-钙粘附素表达降低。在G1、G2和G3子宫内膜样腺癌中，E-钙粘附素表达降低的比例分别为19.5%、40.8%和72.7%。在原发肿瘤中，Snail和Slug的核表达阳性率分别为16.9%和3.7%。EMT状态与组织学类型、FIGO分期、肌层侵袭、腹膜细胞学阳性和患者生存期显著相关(P<；0.01)。原发肿瘤和转移瘤的EMT状态发生率无差异。多变量分析显示EMT阳性状态是无进展生存期和总生存期的显著预测因子(p<；0.01)。结论：这些数据表明子宫内膜癌的EMT状态对预后有影响。因此，阐明和调控EMT信号通路是治疗子宫内膜癌的一种很有前途的分子靶向治疗方法。
Objectives: The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature of this process is the downregulation of E-cadherin expression, which is mainly controlled by Snail-related zinc-finger transcription factors (Snail and Slug). The aim of this study was to evaluate the prognostic impact of EMT-related protein (E-cadherin, Snail and Slug) expression in endometrial cancer. Methods: An immunohistochemical analysis was conducted using tissue microarray samples of 354 primary tumors and 30 metastases of endometrial carcinomas, and the relationship between protein expression, clinicopathological features and outcomes were investigated. Results: Reduced E-cadherin was seen in 39.8% of primary tumors. Reduced E-cadherin was seen in 19.5%, 40.8% and 72.7% of G1, G2 and G3 endometrioid adenocarcinomas, respectively. The nuclear expression of Snail and Slug were positive in 16.9% and 3.7% of primary tumors, respectively. EMT status, which was represented by both reduced E-cadherin and nuclear expression of Snail, was significantly associated with histological type, FIGO stage, myometrial invasion, positive peritoneal cytology and patient survival (p < 0.01). There was no difference in the rates of EMT status between the primary tumors and metastases. A multivariate analysis showed that EMT-positive status was a significant predictor for both the progression-free survival and overall survival (p < 0.01). Conclusions: These data indicate that EMT status has a prognostic impact in endometrial cancer. Therefore, the clarification and control of EMT signaling is a promising molecular targeting therapy in endometrial cancer.
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影响因子：
8
作者：
Grooteclaes, ML;Frisch, SM
通讯作者：
Frisch, SM
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
影响因子：
4
作者：
Bolós, V;Peinado, H;Cano, A
通讯作者：
Cano, A
影响因子：
3.3
作者：
Coppola, D;Fu, L;Jones, M
通讯作者：
Jones, M
影响因子：
5.2
作者：
Kurrey, Nawneet K.;Jalgaonkar, Swati P.;Bapat, Sharmila A.
通讯作者：
Bapat, Sharmila A.