Repeated stress exposure leads to structural synaptic instability prior to disorganization of hippocampal coding and impairments in learning.
Repeated stress exposure leads to structural synaptic instability prior to disorganization of hippocampal coding and impairments in learning.
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DOI：
10.1038/s41398-022-02107-5
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发表时间：
2022-09-12
影响因子：
6.8
通讯作者：
Attardo, Alessio
中科院分区：
文献类型：
--
作者：
Chenani, Alireza;Weston, Ghabiba;Ulivi, Alessandro F.;Castello-Waldow, Tim P.;Huettl, Rosa-Eva;Chen, Alon;Attardo, Alessio
压力会损害大脑结构和功能，导致认知缺陷，并增加患抑郁症、精神分裂症、焦虑症和创伤后应激障碍等精神疾病的风险。特别是，压力暴露会影响海马 CA1 的功能和结构，导致情景记忆受损。在这里，我们应用纵向深脑光学成像来研究暴露于压力的小鼠的活动模式变化和背侧 CA1 锥体神经元的结构可塑性以及海马依赖性学习和记忆之间的联系。我们发现，几天的重复压力导致神经元活动大幅增加，随后这种活动的时间结构和空间编码被破坏。然后，我们追踪了结构兴奋连接的动态，将其作为重复压力引起的活动变化的潜在根本原因。因此，我们发现，反复承受压力会导致脊柱发生立即减少，随后脊柱稳定性下降。相比之下，急性压力导致在时间上接近压力事件时产生的脊柱稳定。重要的是，活动水平、结构连接性和活动模式变化之间的时间关系表明，结构连接性的丧失介导了重复应激暴露后背侧 CA1 的活动增加与时间组织和空间信息内容受损之间的转变。
Stress exposure impairs brain structure and function, resulting in cognitive deficits and increased risk for psychiatric disorders such as depression, schizophrenia, anxiety and post-traumatic stress disorder. In particular, stress exposure affects function and structure of hippocampal CA1 leading to impairments in episodic memory. Here, we applied longitudinal deep-brain optical imaging to investigate the link between changes in activity patterns and structural plasticity of dorsal CA1 pyramidal neurons and hippocampal-dependent learning and memory in mice exposed to stress. We found that several days of repeated stress led to a substantial increase in neuronal activity followed by disruption of the temporal structure of this activity and spatial coding. We then tracked dynamics of structural excitatory connectivity as a potential underlying cause of the changes in activity induced by repeated stress. We thus discovered that exposure to repeated stress leads to an immediate decrease in spinogenesis followed by decrease in spine stability. By comparison, acute stress led to stabilization of the spines born in temporal proximity to the stressful event. Importantly, the temporal relationship between changes in activity levels, structural connectivity and activity patterns, suggests that loss of structural connectivity mediates the transition between increased activity and impairment of temporal organization and spatial information content in dorsal CA1 upon repeated stress exposure.
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影响因子：
64.8
作者：
Hayashi-Takagi A;Yagishita S;Nakamura M;Shirai F;Wu YI;Loshbaugh AL;Kuhlman B;Hahn KM;Kasai H
通讯作者：
Kasai H
影响因子：
64.8
作者：
Attardo A;Fitzgerald JE;Schnitzer MJ
通讯作者：
Schnitzer MJ
影响因子：
16.6
作者：
Frank AC;Huang S;Zhou M;Gdalyahu A;Kastellakis G;Silva TK;Lu E;Wen X;Poirazi P;Trachtenberg JT;Silva AJ
通讯作者：
Silva AJ
DOI：
10.1073/pnas.1003825107
发表时间：
2010-07-20
影响因子：
11.1
作者：
Chen, Yuncai;Rex, Christopher S.;Baram, Tallie Z.
通讯作者：
Baram, Tallie Z.
影响因子：
64.8
作者：
Engert, F;Bonhoeffer, T
通讯作者：
Bonhoeffer, T