canSAR: updated cancer research and drug discovery knowledgebase.
canSAR: updated cancer research and drug discovery knowledgebase.
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DOI：
10.1093/nar/gkt1182
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发表时间：
2014-01
影响因子：
14.9
通讯作者：
Al-Lazikani B
中科院分区：
文献类型：
--
作者：
Bulusu KC;Tym JE;Coker EA;Schierz AC;Al-Lazikani B
canSAR（http：cansar.icr.ac.uk）是一个公共的综合性癌症知识库，用于支持癌症转化研究和药物发现。通过生物学、药理学、化学、结构生物学和蛋白质网络数据的整合，它提供了一个单一的信息门户来回答复杂的多学科问题，包括-在许多其他问题中-关于蛋白质的已知信息，在癌症中表达或突变，以及可以使用什么化学工具和细胞系模型来实验性地探测其活性？关于药物、其细胞敏感性特征以及已知与哪些蛋白质结合可以解释异常生物活性，我们了解多少？在这里，我们描述了canSAR的主要增强功能，包括新数据，改进的搜索和浏览功能以及新靶标，癌细胞系，蛋白质家族和3D结构摘要和工具。
canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused knowledgebase for the support of cancer translational research and drug discovery. Through the integration of biological, pharmacological, chemical, structural biology and protein network data, it provides a single information portal to answer complex multidisciplinary questions including—among many others—what is known about a protein, in which cancers is it expressed or mutated, and what chemical tools and cell line models can be used to experimentally probe its activity? What is known about a drug, its cellular sensitivity profile and what proteins is it known to bind that may explain unusual bioactivity? Here we describe major enhancements to canSAR including new data, improved search and browsing capabilities and new target, cancer cell line, protein family and 3D structure summaries and tools.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Ahmed J;Meinel T;Dunkel M;Murgueitio MS;Adams R;Blasse C;Eckert A;Preissner S;Preissner R
通讯作者：
Preissner R
影响因子：
64.8
作者：
Garnett, Mathew J.;Edelman, Elena J.;Heidorn, Sonja J.;Greenman, Chris D.;Dastur, Anahita;Lau, King Wai;Greninger, Patricia;Thompson, I. Richard;Luo, Xi;Soares, Jorge;Liu, Qingsong;Iorio, Francesco;Surdez, Didier;Chen, Li;Milano, Randy J.;Bignell, Graham R.;Tam, Ah T.;Davies, Helen;Stevenson, Jesse A.;Barthorpe, Syd;Lutz, Stephen R.;Kogera, Fiona;Lawrence, Karl;McLaren-Douglas, Anne;Mitropoulos, Xeni;Mironenko, Tatiana;Thi, Helen;Richardson, Laura;Zhou, Wenjun;Jewitt, Frances;Zhang, Tinghu;O'Brien, Patrick;Boisvert, Jessica L.;Price, Stacey;Hur, Wooyoung;Yang, Wanjuan;Deng, Xianming;Butler, Adam;Choi, Hwan Geun;Chang, JaeWon;Baselga, Jose;Stamenkovic, Ivan;Engelman, Jeffrey A.;Sharma, Sreenath V.;Delattre, Olivier;Saez-Rodriguez, Julio;Gray, Nathanael S.;Settleman, Jeffrey;Futreal, P. Andrew;Haber, Daniel A.;Stratton, Michael R.;Ramaswamy, Sridhar;McDermott, Ultan;Benes, Cyril H.
通讯作者：
Benes, Cyril H.
影响因子：
14.9
作者：
Yang W;Soares J;Greninger P;Edelman EJ;Lightfoot H;Forbes S;Bindal N;Beare D;Smith JA;Thompson IR;Ramaswamy S;Futreal PA;Haber DA;Stratton MR;Benes C;McDermott U;Garnett MJ
通讯作者：
Garnett MJ
DOI：
10.1126/science.1235122
发表时间：
2013-03-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Vogelstein B;Papadopoulos N;Velculescu VE;Zhou S;Diaz LA Jr;Kinzler KW
通讯作者：
Kinzler KW