CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge.
CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge.
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DOI：
10.1093/nar/gkq910
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Preissner R
中科院分区：
文献类型：
--
作者：
Ahmed J;Meinel T;Dunkel M;Murgueitio MS;Adams R;Blasse C;Eckert A;Preissner S;Preissner R
在癌症诊断和治疗方法的开发过程中，产生了大量的信息。新型癌症靶蛋白已被鉴定，许多激活或抑制癌症相关靶基因的化合物也已被开发出来。这些知识基于文献中大量经过实验验证的化合物-目标相互作用，并且文献文本挖掘的摘录分布在众多数据源中。我们自己的分析表明，重要的现有存储库（例如比较毒基因组学数据库 (CTD)、治疗目标数据库 (TTD)、药物基因组学知识库 (PharmGKB) 和 DrugBank）之间的重叠以及我们自己的癌症注释条目文献挖掘之间的重叠惊人地小。为了提供交互数据的简单概述，必须将此信息集成到单个综合数据存储库中。在这里，我们展示了 CancerResource，这是一个数据库，它整合了来自 (i) 我们自己的文献挖掘和 (ii) 外部资源的化合物和靶标的癌症相关关系，并辅以 (iii) 有关基因和细胞效应的基本实验和支持信息。为了便于概览现有信息和支持信息，建立了一系列新颖的信息连接。 CancerResource 致力于自然科学以及个体化医学中化合物与靶点相互作用的研究； CancerResource 可在以下网址获取：http://bioinformatics.charite.de/cancerresource/。
During the development of methods for cancer diagnosis and treatment, a vast amount of information is generated. Novel cancer target proteins have been identified and many compounds that activate or inhibit cancer-relevant target genes have been developed. This knowledge is based on an immense number of experimentally validated compound–target interactions in the literature, and excerpts from literature text mining are spread over numerous data sources. Our own analysis shows that the overlap between important existing repositories such as Comparative Toxicogenomics Database (CTD), Therapeutic Target Database (TTD), Pharmacogenomics Knowledge Base (PharmGKB) and DrugBank as well as between our own literature mining for cancer-annotated entries is surprisingly small. In order to provide an easy overview of interaction data, it is essential to integrate this information into a single, comprehensive data repository. Here, we present CancerResource, a database that integrates cancer-relevant relationships of compounds and targets from (i) our own literature mining and (ii) external resources complemented with (iii) essential experimental and supporting information on genes and cellular effects. In order to facilitate an overview of existing and supporting information, a series of novel information connections have been established. CancerResource addresses the spectrum of research on compound–target interactions in natural sciences as well as in individualized medicine; CancerResource is available at: http://bioinformatics.charite.de/cancerresource/.
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影响因子：
14.9
作者：
Davis AP;Murphy CG;Saraceni-Richards CA;Rosenstein MC;Wiegers TC;Mattingly CJ
通讯作者：
Mattingly CJ
影响因子：
14.9
作者：
Forbes, Simon A.;Tang, Gurpreet;Futreal, P. Andrew
通讯作者：
Futreal, P. Andrew
影响因子：
14.9
作者：
Ruepp, Andreas;Brauner, Barbara;Dunger-Kaltenbach, Irmtraud;Frishman, Goar;Montrone, Corinna;Stransky, Michael;Waegele, Brigitte;Schmidt, Thorsten;Doudieu, Octave Noubibou;Mpflen, Volker Stu;Mewes, H. Werner
通讯作者：
Mewes, H. Werner
药物遗传学和药物基因组学知识库：加强知识。
影响因子：
14.9
作者：
Hernandez-Boussard, Tina;Whirl-Carrillo, Michelle;Hebert, Joan M.;Gong, Li;Owen, Ryan;Gong, Mei;Gor, Winston;Liu, Feng;Truong, Chuong;Whaley, Ryan;Woon, Mark;Zhou, Tina;Altman, Russ B.;Klein, Teri E.
通讯作者：
Klein, Teri E.
影响因子：
3.5
作者：
Mattingly, Carolyn J.
通讯作者：
Mattingly, Carolyn J.