Glymphatic influx and clearance are accelerated by neurovascular coupling.
Glymphatic influx and clearance are accelerated by neurovascular coupling.
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DOI：
10.1038/s41593-023-01327-2
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发表时间：
2023-06
影响因子：
25
通讯作者：
Nedergaard, Maiken
中科院分区：
文献类型：
--
作者：
Holstein-Ronsbo, Stephanie;Gan, Yiming;Giannetto, Michael J.;Rasmussen, Martin Kaag;Sigurdsson, Bjorn;Beinlich, Felix Ralf Michael;Rose, Laura;Untiet, Verena;Hablitz, Lauren M.;Kelley, Douglas H.;Nedergaard, Maiken
功能性充血，也称为神经血管耦合，是当神经活动增加局部脑血流量时发生的现象。因为所有的生物活动都会产生代谢废物，我们在这里试图研究功能性充血和通过胶质淋巴系统清除废物之间的关系。分析表明，晶须刺激增加胶质淋巴流入和清除小鼠体感皮层与1.6倍增加动脉周围脑脊液（CSF）流入速度在激活的半球。粒子跟踪测速显示动脉扩张/收缩和动脉周围脑脊液流速之间的直接耦合。在没有神经激活的情况下，血管平滑肌细胞的光遗传学操作增强了胶质淋巴流入。我们建议，阻抗泵允许动脉脉动驱动CSF在相同的方向作为血流，我们提出了一个模拟，支持这一想法。因此，功能性充血不仅促进代谢物的供应，而且还促进代谢废物的清除。
Functional hyperemia, also known as neurovascular coupling, is a phenomenon that occurs when neural activity increases local cerebral blood flow. Because all biological activity produces metabolic waste, we here sought to investigate the relationship between functional hyperemia and waste clearance via the glymphatic system. The analysis showed that whisker stimulation increased both glymphatic influx and clearance in mouse somatosensory cortex with a 1.6-fold increase in periarterial cerebrospinal fluid (CSF) influx velocity in the activated hemisphere. Particle tracking velocimetry revealed a direct coupling between arterial dilation/constriction and periarterial CSF flow velocity. Optogenetic manipulation of vascular smooth muscle cells enhanced glymphatic influx in the absence of neural activation. We propose that impedance pumping allows arterial pulsatility to drive CSF in the same direction as blood flow, and we present a simulation that supports this idea. Thus, functional hyperemia boosts not only the supply of metabolites, but also removal of metabolic waste.
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DOI：
10.1177/1073858418805427
发表时间：
2019-08
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Drew PJ;Winder AT;Zhang Q
通讯作者：
Zhang Q
影响因子：
13.6
作者：
Da Mesquita S;Herz J;Wall M;Dykstra T;de Lima KA;Norris GT;Dabhi N;Kennedy T;Baker W;Kipnis J
通讯作者：
Kipnis J
影响因子：
64.8
作者：
Drieu, Antoine;Du, Siling;Storck, Steffen E.;Rustenhoven, Justin;Papadopoulos, Zachary;Dykstra, Taitea;Zhong, Fenghe;Kim, Kyungdeok;Blackburn, Susan;Mamuladze, Tornike;Harari, Oscar;Karch, Celeste M.;Bateman, Randall J.;Perrin, Richard;Farlow, Martin;Chhatwal, Jasmeer;Hu, Song;Randolph, Gwendalyn J.;Smirnov, Igor;Kipnis, Jonathan
通讯作者：
Kipnis, Jonathan
DOI：
10.1177/0271678x17737984
发表时间：
2018-04
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Bedussi B;Almasian M;de Vos J;VanBavel E;Bakker EN
通讯作者：
Bakker EN
影响因子：
5.8
作者：
Bohr, Tomas;Hjorth, Poul G.;Holst, Sebastian C.;Hrabetova, Sabina;Kiviniemi, Vesa;Lilius, Tuomas;Lundgaard, Iben;Mardal, Kent-Andre;Martens, Erik A.;Mori, Yuki;Nagerl, U. Valentin;Nicholson, Charles;Tannenbaum, Allen;Thomas, John H.;Tithof, Jeffrey;Benveniste, Helene;Iliff, Jeffrey J.;Kelley, Douglas H.;Nedergaard, Maiken
通讯作者：
Nedergaard, Maiken