Mammalian pheromones.

Mammalian pheromones.
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哺乳动物信息素。

DOI:
10.1146/annurev-physiol-021113-170334
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发表时间:
2014
影响因子:
18.2
通讯作者:
Liberles SD
Liberles SD
中科院分区:
医学1区
文献类型:
--
作者:
Liberles SD

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哺乳动物的信息素控制着无数的先天社会行为,并敏锐地调节激素水平。对信息素的反应是高度鲁棒的,可重复的,和刻板的,可能涉及发育预定的神经回路。本文综述了信息素在哺乳动物中的几个方面,包括:(a)主要嗅上皮和犁鼻器中参与信息素检测的化学感受受体和信号成分,(B)信息素激活的神经回路受性别特异性和状态依赖性的调节,(c)信息素激活的神经回路受性别特异性和状态依赖性的调节。以及(c)哺乳动物信息素的惊人化学多样性,其范围从小的挥发性分子和硫酸化类固醇到大家族的蛋白质。最后,我回顾了(d)各种行为和内分泌反应的分子机制,包括青春期和发情期的调节;生殖,攻击,哺乳和父母的行为控制;个人识别;和区分自己的物种从捕食者,竞争对手和猎物。信息素转导机制的解构为理解气味反应途径如何产生本能行为提供了重要的基础。
Mammalian pheromones control a myriad of innate social behaviors and acutely regulate hormone levels. Responses to pheromones are highly robust, reproducible, and stereotyped and likely involve developmentally predetermined neural circuits. Here, I review several facets of pheromone transduction in mammals, including (a) chemosensory receptors and signaling components of the main olfactory epithelium and vomeronasal organ involved in pheromone detection; (b) pheromone-activated neural circuits subject to sex-specific and state-dependent modulation; and (c) the striking chemical diversity of mammalian pheromones, which range from small, volatile molecules and sulfated steroids to large families of proteins. Finally, I review (d ) molecular mechanisms underlying various behavioral and endocrine responses, including modulation of puberty and estrous; control of reproduction, aggression, suckling, and parental behaviors; individual recognition; and distinguishing of own species from predators, competitors, and prey. Deconstruction of pheromone transduction mechanisms provides a critical foundation for understanding how odor response pathways generate instinctive behaviors.
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