The expression and survival significance of sodium glucose transporters in pancreatic cancer.
The expression and survival significance of sodium glucose transporters in pancreatic cancer.
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钠葡萄糖转运蛋白在胰腺癌中的表达及生存意义
DOI：
10.1186/s12885-021-09060-4
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发表时间：
2022-01-28
期刊：
影响因子：
3.8
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Du J;Gu J;Deng J;Kong L;Guo Y;Jin C;Bao Y;Fu D;Li J
钠葡萄糖转运蛋白 (SGLT) 在许多实体癌（包括胰腺癌 (PC)）的葡萄糖摄取中发挥着至关重要的作用。然而，它们在胰腺癌中的表达谱及其与预后的相关性尚不清楚。因此，我们的目的是分析 SGLT-1 和 SGLT-2 在 PC 中的表达谱和预后意义。该研究纳入2017年7月至2020年6月在复旦大学附属华山医院接受手术的88例胰腺导管腺癌（PDAC）患者。通过手术切除获得免疫组织化学标本。生物信息学分析是基于基因表达综合 (GEO)、Oncomine 和癌症基因组图谱 (TCGA) 数据库进行的。统计数据是使用 IBM SPSS Statistics 版本 20 和 R 4.1.1 计算的。 P值低于0.05被认为表明有统计学意义。 SGLT-1 但不是 SGLT-2 在 PDAC 中显着过表达。生存分析显示，SGLT-1高表达患者的中位总生存期（OS）和无进展生存期（PFS）显着长于SGLT-1低表达患者。 Cox回归表明，SGLT-1高表达是较好预后的独立预测因素，而残留肿瘤状态（R1和R2）是不良预后的独立危险因素。最后，PDZK1相互作用蛋白1（PDZK1IP1）是一种参与活性氧生成的蛋白，在PDAC中过表达，并且其表达与SGLT-1显着相关。 PDAC 中 SGLT-1 而不是 SGLT-2 过表达，SGLT-1 的过表达可能是更好预后的预测因子。残留肿瘤状态（R1 和 R2）是预后不良和疾病进展的危险因素。在线版本包含可在 10.1186/s12885-021-09060-4 获取的补充材料。
Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with prognosis are not clear. Thus, we aimed to analyse the expression profile and prognostic significance of SGLT-1 and SGLT-2 in PC. Eighty-eight patients with pancreatic ductal adenocarcinoma (PDAC) undergoing surgery in Huashan Hospital, Fudan University, from July 2017 to June 2020 were enrolled in the study. Specimens for immunohistochemistry were obtained through surgical resection. Bioinformatics analysis was performed based on the Gene Expression Omnibus (GEO), Oncomine and The Cancer Genome Atlas (TCGA) databases. The statistics were calculated using IBM SPSS Statistics, version 20 and R 4.1.1. P values lower than 0.05 were considered to indicate statistical significance. SGLT-1 but not SGLT-2 was significantly overexpressed in PDAC. Survival analysis showed that the median overall survival (OS) and progression-free survival (PFS) of patients with high SGLT-1 expression were significantly longer than that of patients with low SGLT-1 expression. Cox regression indicated that high SGLT-1 expression was an independent predictor for a better prognosis, while residual tumour status (R1 and R2) was an independent risk factor for a poor prognosis. Finally, PDZK1-interacting protein 1 (PDZK1IP1), a protein participating in the generation of reactive oxygen species, was overexpressed in PDAC and its expression was significantly correlated with SGLT-1. SGLT-1 but not SGLT-2 was overexpressed in PDAC, and the overexpression of SGLT-1 could be a predictor of a better prognosis. Residual tumour status (R1 and R2) was a risk factor for poor prognosis and disease progression. The online version contains supplementary material available at 10.1186/s12885-021-09060-4.
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