Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm.
Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm.
复制标题
肠道微生物组揭示腹主动脉瘤的发生和治疗
DOI：
10.3389/fcvm.2022.1063683
复制
发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
腹主动脉瘤(AAA)是一种致残率高、死亡率高的炎症性血管疾病。其易感危险因素包括高龄、男性、吸烟、高血压和动脉粥样硬化。随着筛查技术的提高，动脉瘤破裂所致AAA的发病率和死亡人数逐年上升，引起了临床的高度重视。由于缺乏非侵入性治疗，早期发现AAA并开发新的治疗方法是临床迫切需要关注的问题。AAA的病理生理和进展以炎性破坏为特征。肠道微生物区系是直接或间接影响血管壁炎性细胞浸润的无形器官，表现为动脉壁微生物区系和代谢产物的增强，在AAA的形成和发展中起着重要作用。因此，肠道微生物群可能成为AAA的重要危险因素。本文综述了肠道微生物组在AAA发病机制中的直接和间接作用，重点介绍了肠道微生物组介导的炎症反应和相关治疗靶点的发现，这些可能有助于控制AAA的发生和破裂。
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease with high disability and mortality. Its susceptible risk factors include old age, being male, smoking, hypertension, and aortic atherosclerosis. With the improvement of screening techniques, AAA incidence and number of deaths caused by aneurysm rupture increase annually, attracting much clinical attention. Due to the lack of non-invasive treatment, early detection and development of novel treatment of AAA is an urgent clinical concern. The pathophysiology and progression of AAA are characterized by inflammatory destruction. The gut microbiota is an “invisible organ” that directly or indirectly affects the vascular wall inflammatory cell infiltration manifested with enhanced arterial wall gut microbiota and metabolites, which plays an important role in the formation and progression of AAA. As such, the gut microbiome may become an important risk factor for AAA. This review summarizes the direct and indirect effects of the gut microbiome on the pathogenesis of AAA and highlights the gut microbiome-mediated inflammatory responses and discoveries of relevant therapeutic targets that may help manage the development and rupture of AAA.
登录
查看更多内容
年龄相关的 Sirtuin 1 血管平滑肌减少与血管衰老和炎症与腹主动脉瘤有关
影响因子：
20.1
作者：
Chen HZ;Wang F;Gao P;Pei JF;Liu Y;Xu TT;Tang X;Fu WY;Lu J;Yan YF;Wang XM;Han L;Zhang ZQ;Zhang R;Zou MH;Liu DP
通讯作者：
Liu DP
影响因子：
9
作者：
Aranson, Nathan J.;Lancaster, Robert T.;Patel, Virendra I.
通讯作者：
Patel, Virendra I.
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
4.4
作者：
Chen, Pei-Chi;Chien, Yi-Wen;Yang, Suh-Ching
通讯作者：
Yang, Suh-Ching
影响因子：
5.3
作者：
Bobryshev, YV;Lord, RSA
通讯作者：
Lord, RSA