Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury.
Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury.
复制标题
康复结合神经祖细胞移植物可实现慢性脊髓损伤的功能恢复。
DOI：
10.1172/jci.insight.158000
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发表时间：
2022-08-22
期刊：
影响因子：
8
通讯作者：
Tuszynski, Mark H.
中科院分区：
文献类型：
--
作者：
Lu, Paul;Freria, Camila M.;Graham, Lori;Tran, Amanda N.;Villarta, Ashley;Yassin, Dena;Huie, J. Russell;Ferguson, Adam R.;Tuszynski, Mark H.
我们以前报道过神经前体细胞（NPC）移植物在亚急性脊髓损伤（SCI）部位形成神经中继并支持功能恢复。在这里，我们研究是否NPC移植慢性延迟后也支持恢复，以及是否强化康复进一步促进恢复。双侧颈部严重挫伤后1个月，大鼠接受每日强化康复治疗、NPC移植或康复和移植。值得注意的是，只有康复和移植的组合显着改善功能恢复。此外，改善的功能结果与宿主皮质脊髓轴突再生到移植物中的康复诱导的增加有关。这些发现确定了康复和神经干细胞治疗在驱动神经可塑性以支持慢性和严重SCI后的功能恢复方面的关键和协同作用。
We reported previously that neural progenitor cell (NPC) grafts form neural relays across sites of subacute spinal cord injury (SCI) and support functional recovery. Here, we examine whether NPC grafts after chronic delays also support recovery and whether intensive rehabilitation further enhances recovery. One month after severe bilateral cervical contusion, rats received daily intensive rehabilitation, NPC grafts, or both rehabilitation and grafts. Notably, only the combination of rehabilitation and grafting significantly improved functional recovery. Moreover, improved functional outcomes were associated with a rehabilitation-induced increase in host corticospinal axon regeneration into grafts. These findings identify a critical and synergistic role of rehabilitation and neural stem cell therapy in driving neural plasticity to support functional recovery after chronic and severe SCI.
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影响因子：
4.2
作者：
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通讯作者：
Tuszynski, Mark Henry
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通讯作者：
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