Origin and evolution of new exons in the rodent zinc finger protein 39 gene
Origin and evolution of new exons in the rodent zinc finger protein 39 gene
复制标题
啮齿动物锌指蛋白39基因新外显子的起源和进化
DOI：
10.1360/982004-743
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发表时间：
2005-06
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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新的结构和功能的起源是进化的一个重要过程。在过去的几十年里，我们对新基因的起源和进化有了一些初步的认识。然而，作为基因的基本单位，外显子的起源和进化至今仍不清楚。由于年轻的外显子保留了起源的足迹，它们可以成为研究新外显子起源和进化的良好材料。本文报道了啮齿类动物锌指蛋白基因的两个年轻外显子。由于它们是小鼠和大鼠基因组中的独特序列，而在人和猪的同源基因中没有发现同源序列，因此年轻外显子可能是在灵长类和啮齿类分化后通过内含子序列的外显子化而产生的。在小鼠和大鼠之间的新外显子中检测到强烈的正选择，表明这些外显子在两个物种分离后发生了显著的功能分化。另一方面，小鼠的群体遗传学数据表明，新的外显子已经受到功能限制，表明新的外显子在小鼠中具有重要的功能。功能分析表明，这些新的外显子编码一个核定位信号肽，这可能介导的核蛋白转运的新途径。据我们所知，这是年轻外显子起源和进化的第一个例子。
The origin of new structures and functions is an important process in evolution. In the past decades, we have obtained some preliminary knowledge of the origin and evolution of new genes. However, as the basic unit of genes, the origin and evolution of exons remain unclear. Because young exons retain the footprints of origination, they can be good materials for studying origin and evolution of new exons. In this paper, we report two young exons in a zinc finger protein gene of rodents. Since they are unique sequences in mouse and rat genome and no homologous sequences were found in the orthologous genes of human and pig, the young exons might originate after the divergence of primates and rodents through exonization of intronic sequences. Strong positive selection was detected in the new exons between mouse and rat, suggesting that these exons have undergone significant functional divergence after the separation of the two species. On the other hand, population genetics data of mouse demonstrate that the new exons have been subject to functional constraint, indicating an important function of the new exons in mouse. Functional analyses suggest that these new exons encode a nuclear localization signal peptide, which may mediate new ways of nuclear protein transport. To our knowledge, this is the first example of the origin and evolution of young exons.
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影响因子：
12.3
作者：
Urrutia R
通讯作者：
Urrutia R
影响因子：
3.3
作者：
N. Shomron;Mika Reznik;G. Ast
通讯作者：
N. Shomron;Mika Reznik;G. Ast
影响因子：
--
作者：
Xin Li;Shuang Yang;Lixin Peng;Hong Chen;Wen Wang
通讯作者：
Xin Li;Shuang Yang;Lixin Peng;Hong Chen;Wen Wang
影响因子：
2.7
作者：
NOCE, T;FUJIWARA, Y;HIGASHINAKAGAWA, T
通讯作者：
HIGASHINAKAGAWA, T
影响因子：
3.5
作者：
Moede, T;Leibiger, B;Leibiger, IB
通讯作者：
Leibiger, IB