Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview.
Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview.
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DOI：
10.3390/ijms222111825
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发表时间：
2021-10-31
影响因子：
5.6
通讯作者：
Buzzaccarini G
中科院分区：
文献类型：
--
作者：
Gullo G;Etrusco A;Cucinella G;Perino A;Chiantera V;Laganà AS;Tomaiuolo R;Vitagliano A;Giampaolino P;Noventa M;Andrisani A;Buzzaccarini G
子宫内膜癌（EC）是一种严重影响妇女生活质量的有害疾病。虽然积极的干预措施应考虑治疗高级别EC，保守的方法应考虑妇女希望怀孕。在这种情况下，我们提出了一个关于EC生育力保留方法的最新技术水平的概述。I型EC在低阶段是唯一的组织学类型，可以解决与生育力保留的方法。此外，不应发现子宫肌层和/或附件侵犯，也不应累及淋巴管间隙。关于药物靶点，孕激素，特别是醋酸甲羟孕酮（MPA）或醋酸甲地孕酮（MA），是早期EC保守治疗中最常用的药物。二甲双胍的使用和宫腔镜评估仍在争论中，尽管有希望的结果。应特别严格和紧迫的关注后续和心理健康的妇女，特别是因为双重有害的损害：EC和EC相关的不孕症的后果。
Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol acetate (MA), are the most employed agent in conservative treatment of early-stage EC. The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences.
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DOI：
10.3390/ph14060504
发表时间：
2021-05-25
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Gambioli R;Forte G;Buzzaccarini G;Unfer V;Laganà AS
通讯作者：
Laganà AS
影响因子：
3.8
作者：
Gunter, Marc J.;Hoover, Donald R.;Strickler, Howard D.
通讯作者：
Strickler, Howard D.
影响因子：
4.8
作者：
Chae, Su Hyun;Shim, Seung-Hyuk;Kang, Soon-Beom
通讯作者：
Kang, Soon-Beom
影响因子：
9.8
作者：
Cheang, Kai I.;Baillargeon, Jean-Patrice;Nestler, John E.
通讯作者：
Nestler, John E.
影响因子：
2
作者：
Heimark, Douglas;McAllister, Jan;Larner, Joseph
通讯作者：
Larner, Joseph