Myo-Inositol as a Key Supporter of Fertility and Physiological Gestation.
Myo-Inositol as a Key Supporter of Fertility and Physiological Gestation.
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DOI：
10.3390/ph14060504
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发表时间：
2021-05-25
期刊：
影响因子：
--
通讯作者：
Laganà AS
中科院分区：
文献类型：
--
作者：
Gambioli R;Forte G;Buzzaccarini G;Unfer V;Laganà AS
怀孕是一个复杂的过程，表现为女性生理上的几个必要变化。大多数妇女都经历了健康的怀孕；即使如此，也有一些妇女经历了生育力下降或与怀孕有关的病理变化。在过去的几年里，研究人员调查了几种作为生育促进剂的分子。其中，肌醇(myo-ins)是一种安全的化合物，在与生育和怀孕有关的问题上被证明是有用的。事实上，myo-ins参与了几个信号传递过程，包括胰岛素和促性腺激素的途径，因此，它很可能对生育有积极的影响。特别是，几项临床试验表明，给药对不孕妇女有治疗效果，也可以作为怀孕期间的预防治疗。特别是，myo-ins可以预防神经管缺陷的发生和妊娠期糖尿病的发生，促进无障碍妊娠。由于肌动蛋白的安全性和有效性，这种治疗方法还可以替代怀孕期间禁忌的几种药物。
Pregnancy is a complex process, featuring several necessary changes in women’s physiology. Most women undergo healthy pregnancies; even so, several women experience reduced fertility or pathologies related to the pregnancy. In the last years, researchers investigated several molecules as promoters of fertility. Among all, myo-inositol (myo-ins) represents a safe compound that proved useful in issues related to fertility and pregnancy. In fact, myo-ins participates in several signaling processes, including the pathways of insulin and gonadotropins, and, therefore, it is likely to positively affect fertility. In particular, several clinical trials demonstrate that its administration can have therapeutic effects in infertile women, and that it can also be useful as a preventive treatment during pregnancy. Particularly, myo-ins could prevent the onset of neural tube defects and the occurrence of gestational diabetes mellitus, promoting a trouble-free gestation. Due to the safety and efficiency of myo-ins, such a treatment may also substitute several pharmaceuticals, which are contraindicated in pregnancy.
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影响因子：
16.2
作者：
D'Anna R;Scilipoti A;Giordano D;Caruso C;Cannata ML;Interdonato ML;Corrado F;Di Benedetto A
通讯作者：
Di Benedetto A
DOI：
10.1038/nrdp.2015.7
发表时间：
2015-04-30
期刊：
Nature reviews. Disease primers
影响因子：
--
作者：
Copp AJ;Adzick NS;Chitty LS;Fletcher JM;Holmbeck GN;Shaw GM
通讯作者：
Shaw GM
DOI：
10.1093/advances/nmaa100
发表时间：
2021-02-01
期刊：
Advances in nutrition (Bethesda, Md.)
影响因子：
--
作者：
D'Souza SW;Copp AJ;Greene NDE;Glazier JD
通讯作者：
Glazier JD
影响因子：
6.1
作者：
Chiu, TTY;Rogers, MS;Haines, CJ
通讯作者：
Haines, CJ
影响因子：
2
作者：
D'Anna, R.;Di Benedetto, V.;Di Benedetto, A.
通讯作者：
Di Benedetto, A.