Brain activation induced by chronic psychosocial stress in mice.
Brain activation induced by chronic psychosocial stress in mice.
复制标题
DOI：
10.1038/s41598-017-15422-5
复制
发表时间：
2017-11-08
影响因子：
4.6
通讯作者：
Hovatta I
中科院分区：
文献类型：
--
作者：
Laine MA;Sokolowska E;Dudek M;Callan SA;Hyytiä P;Hovatta I
慢性心理社会压力是神经精神疾病的一个公认的危险因素。在患有与压力有关的疾病的患者中，已经证明了大脑活动的减少。慢性应激暴露期间的全球大脑激活模式不太清楚，但可能对特定的大脑回路有很强的修饰作用，从而影响应激相关病理的发展。我们确定了慢性社会失败压力诱导的神经激活，这是一种心理社会压力的小鼠模型。为了评估无偏见的全脑焦点的慢性激活，我们使用了锰增强磁共振成像（MEMRI）和免疫组化染色的MANFOSB，一个转录因子诱导的重复神经活动。在10天的社交失败后一周，我们观察到与对照小鼠相比，在几个已知调节抑郁和焦虑样行为的大脑区域中显着更多的激活，包括前额叶皮层，终纹床核，腹侧海马和中脑导水管周围灰质。我们进一步确定，在慢性社交失败后，特定脑区之间的CARFOSB阳性细胞的相关性发生了改变。这些神经回路的慢性激活可能与慢性心理社会压力暴露期间发生的持续性大脑活动变化有关，与人类焦虑和抑郁的发展具有潜在相关性。
Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus and periaqueductal grey in stressed compared to control mice. We further established that the correlation of ∆FOSB positive cells between specific brain regions was altered following chronic social defeat. Chronic activation of these neural circuits may relate to persistent brain activity changes occurring during chronic psychosocial stress exposure, with potential relevance for the development of anxiety and depression in humans.
登录
查看更多内容
DOI：
10.1111/j.1460-9568.2012.08161.x
发表时间：
2012-08
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Flak JN;Solomon MB;Jankord R;Krause EG;Herman JP
通讯作者：
Herman JP
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.1
作者：
Inoue T;Majid T;Pautler RG
通讯作者：
Pautler RG
影响因子：
3.4
作者：
Carle, Tiffany L.;Ohnishi, Yoshinori N.;Nestler, Eric J.
通讯作者：
Nestler, Eric J.
影响因子：
3.6
作者：
Krueger, Oliver;Shiozawa, Thomas;Ethofer, Thomas
通讯作者：
Ethofer, Thomas